Research Specialist - Clinical Pharmacology and Analytical Chemistry (CPAC) Laboratory

Updated: about 1 month ago
Location: Chapel Hill, NORTH CAROLINA
Job Type: FullTime
Deadline: 04 Jun 2024

Posting Information
Posting Information

Department SOP-DPET-452200
Career Area Research Professionals
Posting Open Date 05/21/2024
Application Deadline 06/04/2024
Open Until Filled No
Position Type Permanent Staff (EHRA NF)
Working Title Research Specialist - Clinical Pharmacology and Analytical Chemistry (CPAC) Laboratory
Appointment Type EHRA Non-Faculty
Position Number 00008671
Vacancy ID NF0008163
Full Time/Part Time Full-Time Permanent
Hours per week 40
Position Location North Carolina, US
Hiring Range $61,937 - $68,819
Proposed Start Date 06/03/2024

Position Information

Be a Tar Heel!
A global higher education leader in innovative teaching, research and public service, the University of North Carolina at Chapel Hill consistently ranks as one of the nation’s top public universities . Known for its beautiful campus, world-class medical care, commitment to the arts and top athletic programs, Carolina is an ideal place to teach, work and learn.
One of the best college towns and best places to live in the United States, Chapel Hill has diverse social, cultural, recreation and professional opportunities that span the campus and community.
University employees can choose from a wide range of professional training opportunities for career growth, skill development and lifelong learning and enjoy exclusive perks for numerous retail, restaurant and performing arts discounts, savings on local child care centers and special rates on select campus events. UNC-Chapel Hill offers full-time employees a comprehensive benefits package , paid leave, and a variety of health, life and retirement plans and additional programs that support a healthy work/life balance.
Primary Purpose of Organizational Unit
The UNC Eshelman School of Pharmacy ( is one of six health science schools (Pharmacy, Nursing, Dentistry, Social Work, Public Health, Medicine) at the University of North Carolina at Chapel Hill and is one of the oldest health science academic programs at Chapel Hill. The School teaches approximately 600 PharmD students and 145 graduate students. The School has built a reputation for its continued pursuit of excellence, rigorous education and training programs, cutting-edge multidisciplinary research, progressive pharmacy practices, efficient business operations, and its outstanding faculty, staff, and students. The School was named the number one School of Pharmacy in the U.S. by the U.S. News and World Report. The School has experienced unprecedented growth and success and continues to strategically position itself for sustained impact, as articulated in the School’s Strategic Plan (
Our Vision is to be the global leader in pharmacy and pharmaceutical sciences. Our Mission is to prepare leaders and innovators to solve the world’s most pressing health care challenges. We are Advancing Medicine for Life through innovation and collaboration in pharmacy practice, education, research, and public service.
Position Summary
The Clinical Pharmacology and Analytical Chemistry (CPAC) Laboratory, within the UNC Eshelman School of Pharmacy, is an internationally recognized lab focused on facilitating the development of safe, effective strategies for HIV prevention, treatment, and cure. The group comprises clinical, translational, and bioanalytical scientists dedicated to conducting preclinical and clinical pharmacology research on current and investigational new drugs to optimize drug therapy outcomes. Central to this work is the quantitative analysis of small molecules in a variety of biological matrices using mass spectrometry. In addition to traditional LC-MS methods, we implement a unique approach for mass spectrometry imaging (MSI) that can measure the spatial distributions of target analytes to better understand drug penetration.
The UNC Eshelman School of Pharmacy is seeking a qualified analytical chemist for a full-time position as a research specialist within the CPAC Laboratory. The primary purpose of this position is to analyze biological samples for drug and endogenous compound concentrations, primarily by infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI. These analyses support the grants and contracts of the CPAC lab, the UNC Center for AIDS Research, and the UNC CARE Collaboratory for Eradication of HIV
Responsibilities of this position include:
* Independently performing timely, accurate and precise sample analysis by IR-MALDESI MSI using developed bioanalytical methods of drug or endogenous compound concentrations in animal and human biological matrices. 
* Performing experimental data reduction and visualization of mass spectrometry imaging output using developed workflows. This includes making deductions from resulting data and preparing detailed findings on results for quality assurance review and approval.
* Preparing stock solutions, calibrations standards, and QC samples for bioanalytical assays.
* Maintaining up-to-date laboratory records and documentation. 
* Ensuring IR-MALDESI MSI equipment maintenance is up to date and managing supply levels for consumables.
* Participating in method qualification and validation activities for new assays.
Minimum Education and Experience Requirements
Bachelor’s degree in a discipline related to the area of assignment; or equivalent combination of training and experience. All degrees must be received from appropriately accredited institutions.
Required Qualifications, Competencies, and Experience
* Laboratory experience, preferably in pharmacology or biomedical research
* Understanding of mass spectrometry.
* Ability to identify research objectives, methods and quality control measures based on scientific literature.
* Ability to monitor and collect research data to assess bioanalytical analyses accuracy, validity and integrity.
* Capable of supporting multiple project timelines simultaneously through excellent organizational skills
* Accurate and detailed record-keeping practices
* Proficiency with MS Office products (Word, Excel, PowerPoint) 
* Ability to clearly and concisely convey information verbally and in written form.
Preferred Qualifications, Competencies, and Experience
* Demonstrated ability to troubleshoot/optimize experimental processes based on interpretation of preliminary data
* Working experience in a GLP environment and experience in a BSL2 setting, with a demonstrated safety record.
* Experience with mass spectrometry imaging and the operation and maintenance of mass spectrometers, especially Thermo Orbitraps.
* Knowledge of LC-MS/MS sample preparation and extraction 
* Experience with microtomy and cryosectioning.
* Experience with image analysis and image correlation, 
* Competency with interpretation and evaluation of scientific results and performing statistical analyses on data, and preparing reports and presentations 
* Competency in scientific writing, including preparation of reports, and preparation of oral presentations,
Special Physical/Mental Requirements
Campus Security Authority Responsibilities

Not Applicable.

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Posting Contact Information

Department Contact Name and Title Mac Balatico, HR Business Partner
Department Contact Telephone or Email [email protected]
Office of Human Resources Contact Information

If you experience any problems accessing the system or have questions about the application process, please contact the Office of Human Resources at (919) 843-2300 or send an email to [email protected]
Please note: The Office of Human Resources will not be able to provide specific updates regarding position or application status.

Equal Opportunity Employer Statement
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or status as a protected veteran.

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