RESEARCH SCIENTIST/ENGINEER 3

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POSITION PURPOSE
Our lab is focused on understanding intratumoral heterogeneity in glioblastoma. We have shown in the past that cells within a tumor have dramatically different gene expression profiles. We use cutting edge techniques for single cell analysis such as single cell RNA-seq to interrogate tumor heterogeneity in primary patient samples that are harvested directly from the operating room. In parallel, we are trying to develop and characterize mouse and human culture models that recapitulate the heterogeneity seen in patient tumors in order to allow us to study how these processes affect treatment resistance and tumor evolution. These models include mouse xenografts, genetic mouse models, and human tissue culture models such as neurospheres and brain organoids.

DUTIES AND RESPONSIBILITIES
This Research Scientist/Engineer 3 (E S UAW RSE) position will play an important role in the development and maintenance of bioinformatics pipelines used for QC and processing of high-throughput sequencing data as well as in the integrated analysis of large datasets. This position requires the ability to apply R and python algorithms to extract meaningful insight from complex omics data. Additional skills needed for this position include: HPC, bash scripting, machine learning, and Linux OS.

Bioinformatics Management: 90%