Principal Scientist, Transporter Sciences

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

In this role, you will be joining a dynamic group within the Pharmacokinetics, Dynamics and Metabolism (PDM) at Pfizer's Groton, Connecticut campus, and will focus on the design and execution of strategies to evaluate Transporter-based disposition and pharmacokinetics to drive drug discovery and development programs across Pfizer's therapeutic areas including oncology, internal medicine, inflammation and immunology, and rare diseases.

Working collaboratively with project teams, you will implement experimental techniques such as cell-based assays and in vivo studies to build the understanding on drug transporters involvement in PK and drug-drug interactions (DDIs) for the candidate drugs and provide data-driven insights to inform discovery/design and clinical development strategies.

As a Principal Scientist, you will be recognized as a technical expert in design and execution of experimental in transporter assays and mechanistic ADME studies. Key to the role is an ability to propose develop strategies and execute approaches to address complex ADME/PK questions and an ability to learn, apply and champion novel concepts and technologies. You will undertake mentoring activities to guide team members.It is your hard work and dedication that will make Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Apply technical and functional knowledge to design experiments and independently support quantitative endpoint analysis, particularly in the transporter sciences, and broadly in ADME profiling.
• Design, execute and interpret in vitro transport studies independently, with ability to effectively communicate information to counterparts.
• Provide scientific leadership and transporter knowledge or expertise for lab-based portfolio support and scientific innovation relevant to ADME sciences.
• Interact across groups to advance transporter sciences tool kit and quantitative translational strategies via modeling and simulations.
• Help define and to guide the science, culture, and evolution of the Transporters group. Maintain a 'cutting edge' awareness of technical developments and scientific advancements in the field and apply these innovatively to advance internal capabilities.
• In partnership with counterpart scientific leaders, ensures effective use of internal and external resources of experimental labs across ADME Sciences to deliver key portfolio impact.
• Advances scientific and technology innovation and excellence that translate to portfolio impact and novel and enhanced workflows.
• Maximizes the individual development and performance contributions of matrix team members.
• Create and communicate integrative presentations of biopharma. strategy, dataand interpretation to audiences at different levels of knowledge and expertise.

Qualifications

• Ph.D. in Pharmaceutical sciences, Pharmacokinetics, Clinical Pharmacology or equivalent, with 3-6 years of experience relevant to drug discovery, ADME sciences, cell biology, pharmacology, or related discipline.
• Experience in the design, execution, and analysis of cellular, molecular, and/or biochemical assays focused on understanding drug transport and metabolism.
• Familiarity with PK modeling and simulation concepts and tools.
• Strong teamwork and collaboration within multi-disciplinary matrix teams leading to delivery of project objectives.
• Demonstrated experience coaching peers and team members. Ability to align, motivate, and support a team in defining and working efficiently toward project objectives.
• Interpersonal skills to constructively challenge other scientists to ensure the group as a whole performs at a high level.
• Ability to manage competing priorities and demonstrates ability to prioritize and make decisions to maximize value and resource allocation.
• Demonstrated track record of independent research and scientific publications in peer reviewed journals.
• Strong written/verbal communication skills and ability to collaborate effectively with scientists across related disciplines.

PHYSICAL/MENTAL REQUIREMENTS

Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and work on a computer (while standing or sitting).

Relocation support available

Work Location Assignment:On Premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development