Postdoctoral Fellow – Thoracic and Head & Neck Medical Oncology

Postdoctoral Fellow – Thoracic and Head &Neck Medical Oncology – KRAS -mutant non-small cell lung cancer (NSCLC)

Postdoctoral positions are available to study molecular mechanisms associated with therapeutic response and resistance to RAS inhibition in non-small cell lung cancer (NSCLC) in the laboratory of Ferdinandos Skoulidis, MD, PhD at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab is largely interested in understanding the molecular diversity of KRAS -mutant NSCLC and developing rational and tailored treatment strategies for patients bearing KRAS -mutant lung tumors. We utilize a multifaceted approach that encompasses preclinical studies in immune competent syngeneic and genetically engineered co-mutational models of KRAS - mutant NSCLC as well as PDX/CDXs, in vitro models and large collections of well annotated clinical specimens. We employ state of the art computational biology/bioinformatics approaches to dissect acute and adaptive responses to RAS inhibition in vitro and in vivo . We are committed to a question-driven approach that seeks to address the most urgent clinically relevant scientific questions. Applicants with experience in any of these areas and a true passion for cutting-edge bench to bedside research are encouraged to apply and provide three professional references.

LEARNING OBJECTIVES

Trainees will perform basic and translational research involving molecular biology approaches (such as CRISPR/Cas technology, Western blotting, ELISA, immunohistochemistry), in vitro assays (such as drug screening, flow cytometry, development of resistant cell lines) and in vivo experiments using xenograft, syngeneic and genetically engineered mouse models of KRAS -mutant lung cancer. Candidates with prior experience in computational biology will acquire additional skills and be involved in the analysis of single cell RNA Sequencing, WES and in situ transcriptomics data. Trainees will present their findings at regular lab meetings, departmental seminars, and national conferences. Trainees will submit their findings for publication in peer-reviewed scientific journals.

Eligibility Requirements

Applications are invited from qualified individuals interested in working in a translational research lab; with a PhD and/or MD. The ideal candidate(s) should have less than 2 years of prior postdoctoral experience and have a background in cancer or cell and molecular biology. Experience in RAS signaling and targeting and studies involving mouse models of KRAS-driven cancers is preferred. We are also looking for applicants with prior expertise in computational biology and bioinformatics including analysis of single cell RNA sequencing data and in situ transciptomics. Candidates should be innovative thinkers and highly motivated to pursue an independent career in biomedical research.

Job Knowledge And Skills

• Enthusiastic, highly self-motivated candidate with the ability to think and function independently
• A strong background in cancer biology or cell and molecular biology. Prior experience in RAS signaling and/or targeting is preferred
• Expertise in computational biology/bioinformatics (including proficiency in Python/R) would be desirable, though this skill is not essential
• Prior experience with studies involving mice, including both xenograft/syngeneic models and genetically engineered mice is preferred
• Dedication to basic research, a true "drive", is important
• Collegial nature and ability to work well as part of a team
• Excellent command of written and spoken English language
• Prior publication record with at least one published manuscript as first author

POSITION INFORMATION

MD Anderson follows the NIH stipend levels as outlined by the "Kirchstein - NRSA". This full-time trainee position will provide a salary between $56,484 to $68,604, dependent upon the years of postgraduate experience.

MD Anderson offers compensated trainees:

• Paid medical benefits (zero premium) starting on first day for trainees who work 30 or more hours per week
• Group Dental, Vision, Life, AD&D and Disability coverage
• Paid Education Vacation and Sick Leave
• Paid institutional holidays, wellness leave, childcare leave and other paid leave programs
• Teachers Retirement System defined-benefit pension plan and two voluntary retirement plans
• Employer paid life, AD&D and an illness-related reduced salary pay program
• Health Savings Account and Dependent Care Reimbursement flexible spending accounts
• Fertility benefits
• State of Texas longevity pay
• Extensive wellness, fitness, employee health programs and employee resource groups
• Extensive wellness, fitness, employee health programs and employee resource groups

FACULTY MENTOR

Ferdinandos Skoulidis, MD, PhD