Updated: 1 day ago
Location: Indiana, PENNSYLVANIA
Deadline: ;
Posting Details
Position Details
| Title | Postdoctoral Fellow in Pathology & Laboratory Medicine (Neurodegenerative Diseases) |
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| Specific Title | |
| Appointment Type | Postdoctoral Fellow |
| Department | IUSM - Pathology & Laboratory Medicine |
| Campus | IU School of Medicine Indianapolis |
| Position Summary | The Dementia Laboratory, co-led by Drs. Bernardino Ghetti and Kathy L. Newell of the Indiana University School of Medicine Department of Pathology and Laboratory Medicine Division of Neuropathology, has immediate full-time openings for one or more outstanding, highly motivated post-doctoral research fellows with special interest in molecular pathology of neurodegeneration related to aging as well as sporadic and genetically-determined dementias and motor neuron diseases. These include Alzheimer’s Disease, Frontotemporal Dementias, Parkinson’s Disease, Amyotrophic Lateral Sclerosis and Prion Diseases. The faculty of the laboratory are well funded including having been awarded several NIA and NINDS grants, which involve local, national and international collaborations with leading scientists. Research data is published in high impact factor and high quality journals. This fellowship, provides the opportunity to develop and expand knowledge in the neuropathology of human neurodegenerative diseases using light microscopy, immunohistochemistry, electron microscopy, immunoelectron microscopy, fluorescent multiplex immunohistochemistry, digital spatial profiling, quantitative digital image analysis, and cryo electron microscopy. Additionally, fellows have the opportunity to participate in and develop multidisciplinary projects integrating neuropathology with cutting-edge brain imaging, clinical neurology, protein chemistry, and molecular genetics as well as communicate and collaborate with leading researchers from around the world. Fellows may focus on one or more misfolded proteins and acquire an understanding of co-pathologies of amyloids simultaneously involving a single anatomical system. The Dementia Laboratory’s focus is on the molecular neuropathology of neurodegenerative diseases. Our aims are to expand our knowledge of the mechanisms of neurodegeneration. Neurodegenerative diseases may first affect language, cognition, motor systems, and emotions. It is necessary to identify the anatomical areas and systems primarily affected. Specifically, we strive to understand the earliest stages of intracellular alterations in the anatomical areas whose function appears to be involved in the earliest clinical symptoms. From there, we follow the progression and spread of the neurodegenerative process to anatomical areas that are synaptically connected to the regions primarily affected. Our efforts help to clarify the architecture of the neurodegenerative process. Neuropathology, biochemistry and molecular genetics aid in elucidating the stages of neurodegeneration in individual anatomical areas through the analysis of diseases studied postmortem on individuals who were at different stages of the disease process at the time of their passing. The Dementia Laboratory consists of faculty, staff and students focused on expanding the knowledge on neurodegeneration and the associated misfoled proteins. It provides an environment for a multidisciplinary approach to the study of neurodegenerative dementias. The Dementia Laboratory’s Brain Library contains specimens from well over 2500 individuals collected over the past 45 years offering a unique opportunity to study a wide range of neurodegenerative diseases occurring in a variety of ages, sexes, and racial and ethnic groups. Indiana University School of Medicine – As the nation’s largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity, and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an anti-racist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and wellbeing for all throughout the state of Indiana. Indianapolis – Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life – the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named “Best Airport in North America” by Airports Council International for many years. |
| Basic Qualifications |
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| Department Contact for Questions | Kathy L. Newell, M.D. Department of Pathology and Laboratory Medicine Indiana University School of Medicine e-mail: [email protected] |
| Additional Qualifications |
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| Special Instructions | Please provide a complete CV, three references, and a letter of interest. Your letter of interest should include a brief description of your research experience, interests and goals. |
| Priority Application Review Deadline | |
| Expected Start Date | |
| OAA # | IUSM-01901-2024 |