We are a highly translational laboratory studies colorectal (CRC) and pancreatic (PC) cancers with a focus in liver metastases and the tumor microenvironment (TME). The lab (PI, Rui Wang, PhD) is at Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH. Current focus:
- Characterize roles of liver stromal cells (endothelium, hepatocytes, and others) in GI cancer liver metastases growth, response to chemotherapy, metabolism, and other pro-survival pathways (e.g. HER3)
- Combination therapies of targeting HER3- and other pro-survival pathways
- Cancer-liver stromal cell crosstalk.
The candidate will lead on projects to determine the effects of liver endothelial cells (EC), immune cells, and other TME cell types, on primary tumors and liver metastases in CRC and PC. Lab work will involve tissue culture; patient tissue handling (cryo-preserving, isolating primary cells, developing organoids and PDXs); DNA, RNA, and protein-related assays; cell growth and death assays; animal work (xenograft tumor models, PDX, breeding); basic transcriptomics, proteomics, and metabolomics analysis. Additionally, studies will interface with experts in pathology, biostatistics, medicinal chemistry and other specialties. The candidate is expected to prepare manuscripts and contribute preliminary data, background and significance and experimental design for grant proposals. Under the guidance of the PI, the candidate should be able to work independently, read and critically interpret the literature, assist with designing and planning of projects, oversee collaborations, supervise students, manage animal models, and to carry out research on the assigned project. The candidate is encouraged to apply for grants and present at local and national meetings. Importantly, the fellow must work well with others, and have a desire to help cancer patients as a principal motivation for their work.
More infomration about the PI and lab: https://case.edu/cancer/members/member-directory/rui-wang
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