Postdoctoral Fellow - Immune-oncology, Vaccinology and Immunology

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Postdoctoral Fellowship opportunity is immediately available for a highly motivated individual in the laboratory of Dr. Larry Kwak.  For more information on Dr. Kwak’s research please visit here .

As a successful candidate, you will:

·         Study pre-clinical study for a personalized mRNA cancer vaccine against lymphoma.

·         Use single-cell RNA analysis, you will study cell-intrinsic characteristics of BAFF-R CAR-T correlated with responses that can be used as markers of clinical outcomes.

·         Skills that are used in the lab include: working with mice, mammalian cell culture, primary human cell (BM and PBMC) culture and handling, multi-color FLOW cytometry, ELISA, and cell-sorting, co-culture functional assays.

·         Be familiar with novel single-cell RNA sequencing technologies and analysis pipelines.

·         Highly motivated and self-directed applicants interested in translational research in cancer immunotherapy are strongly encouraged to apply. However, applicants with related training and experience will be given priority.

·         Ph.D. degree with research experience; a track record of publications in peer-reviewed scientific journals.

·         Strong background in immune-oncology, vaccinology and/or immunology.

·         Expertise in multi-parameter FLOW cytometry.

·         Expertise in cell-based assays (e.g. co-culture functional assays, multi-color flow cytometry, ELISA, cell sorting, etc.)

·         Experience executing primary immune cell assays and mechanism of action studies (T cell isolation, expansion, cytokine secretion assays, T cell differentiation, T cell killing assay etc).

Additional Information:

For more scientific background, please refer to our publications:

o   Science 2002 Nov 1; 298(5595):1025-9:       https://doi.org/10.1126/science.1075565

o   Nature Medicine 2005 Sep; 11(9): 986-91:   https://doi.org/10.1038/nm1290

o   BMC Cancer 2018 Feb 13;18(1):                    https://doi.org/10.1186/s12885-018-4094-2

o   Sci Transl Med 2019 Sep 25.              https://doi.org/10.1126/scitranslmed.aaw9414

o   Blood volume 136, Supplement 1 2020 Nov https://doi.org/10.1182/blood-2020-140007

o   Blood 2022 Mar 3                                              https://doi.org/10.1182/blood.2020008493

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here