Job Opportunity: Postdoctoral fellow, Hsieh Laboratory at University of Colorado Anschutz Medical Campus (CU-AMC), Aurora, CO

Posted by hagansa2 on Monday, March 4, 2024 in Job Opportunities .

The Hsieh Laboratory at University of Colorado Anschutz Medical Campus (CU-AMC) is looking for a full-time postdoctoral fellow in the field of Inborn Errors of Immunity (IEI) for an NIH-funded project focused on understanding COVID vaccine-elicited immune response in B cell immunodeficiency.
We are a laboratory that studies 1) “classic autoimmunity” (i.e., lupus) and 2) inborn errors of immunity (IEI) that present with autoimmunity/inflammation. Using primary human samples, in vitro cell lines, and CRISPR/Cas engineered mouse models of human disease, we identify and study novel IEI to dissect the molecular and cellular mechanisms that govern self-tolerance and anti-microbial immunity and provide critical insights for effective therapies in immunodeficiency, autoimmunity/inflammation, and malignancy.

Primary Duties and Responsibilities

• Manage a research project
• Work collaboratively with other lab members and mentor (under)graduate students
•  Critical evaluation of the scientific literature, write manuscripts, and grants
• Maintain compliance for human and animal research conduct, and good laboratory practice

Preferred Qualifications
• Experience with human immunology research in autoimmunity and/or IEI
• Experience with tissue culture, mouse work, and flow cytometry
• Experience with unsupervised high-dimensional single cell cytometry and/or sequencing data

Minimum requirements

•  PhD in Immunology, and/or MD degree and a strong background in immunology, including high-quality first-author publications in the field of immunology

The Successful Candidate Will Learn (be trained) to Design, Implement, and Analyze:

• High-dimensional single-cell cutting edge technologies such as mass cytometry (CyTOF) and single-cell RNA sequencing (scRNASeq)
• Multiparametric single-cell tissue imaging platforms such as multiplexed ion beam imaging (MIBI) and spatial transcriptomics analysis

Environment
Dr. Hsieh is an NIH-funded physician-scientist Associate Professor in the department of Pediatrics, Section of Allergy and Immunology, and her laboratory and trainees reside in the department of Immunology and Microbiology. She is the director for the Jeffery Modell Primary Immunodeficiency Center at Children’s Hospital Colorado. She is also the PI of an IEI patient biobank, collaborates with national and international investigators in the field of IEI, such as the COVID Human Genetic Effort, and leads the Sanford Children’s Genomic Medicine consortium project focused on IEI. She is also the director for the FOCIS Center of Excellence at the University of Colorado, which supports education and training in basic science and clinical immunology. CU-AMC has a strong focus on immunology across
multiple disciplines, exemplified by multiple campus-wide NIH funded initiatives, such as the Center for Mucosal Immunology and Rheumatic Disease Pathogenesis, the Diabetes Research Center, Tissue Interrogation site for the Kidney Precision Medicine Program, GI and Liver Innate Immune Program, the RNA Bioscience Initiative, and the Human Immunology and Immunotherapy Initiative.

How to apply:

Interested applicants should send a cover letter, CV (or NIH Bioksetch), and three references to Dr. Elena Hsieh, [email protected] .

Tags: Job Posting: Postdoc