Cryo-EM Structure Biologist

The Pomerantz lab at Thomas Jefferson University in Philadelphia seeks a Research Associate or Senior Scientist to conduct cryo-electron microscopy (cryo-EM) structure biology and biochemical research on DNA repair proteins involved in cancer proliferation. The position requires a PhD, a minimum of 3 years of experience in cryo-electron microscopy methods and solving high-resolution cryo-EM structures, and a minumum of 5 years of experience in protein biochemistry and molecular biology. The preferred candidate will have expertise in the structure biology of nucleic-acid enzymes.

The research associate will carry out structure biology and biochemical experiments as part of a team of bio-medical researchers to develop small-molecule inhibitors of DNA repair proteins involved in cancer proliferation. The research associate will be required to independently design experimental procedures and interpret results, form hypotheses, and train and mentor research personnel and graduate students on cryo-electron microscopy techniques and other structure biology techniques.The research associate will record and analyze experimental results and collaborate effectively with other team members. Other responsibilities include help maintaining databases of technical methods and protocols, plasmids, and other key resources, maintain accurate records, troubleshoot experimental design malfunctions and implement solutions.