Cheng Lab - Full Specialist

Details

Posted: 20-May-24

Location: San Francisco, California

Type: Full-time

Salary: Open

Categories:

Academic/Faculty

Internal Number: JPF05090

Cheng Lab - Full Specialist
Department of Biochemistry and Biophysics
UC San Francisco

The Cheng Lab is recruiting at the Full rank in the Specialist series to carry out a research project aiming to elucidate structural mechanisms of integrin avb8 and avb6 mediated L-TGF-b activation, and to develop technology to study interactions between full length avb8 and L-TGF-b/GARP embedded in lipid environment by cryo-EM, both single particle and electron tomography. Other research activities include structural, biochemical and functional characterization of antibodies developed against integrins.

Required Qualifications:

• PhD (or equivalent degree) in structural biology or related field or ten or more years of experience in the relevant specialization.
• 4+ years of postdoctoral training experience.
• Proficiency in:
  • Molecular biology,
  • Protein expression using various expression systems including mammalian, bacterial, insect and yeast,
  • Protein biochemistry,
  • All aspects of single particle electron microscopy (including sample preparation for negative stain and cryo-EM, operating electron microscopes, and acquiring high-quality cryo-EM data, and using various single particle cryo-EM image processing packages for high-resolution structure determination),
  • Atomic model building and refinement based on cryo-EM density maps, and
  • Extending and integrating structural analyses of integrin.

Preferred Qualifications:

• 4+ years postdoctoral training experience in a laboratory that specializes in structural biology of membrane proteins with extensive flexibility.
• Preference will be given to candidates with hands-on experience in structural biology integrins and/or related molecules.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $86,900-$181,800.

Please apply online at: https://aprecruit.ucsf.edu/JPF05090 with a cover letter, CV and contact information for two references. Applicant materials must list current and/or pending qualifications upon submission. The selected candidate must meet all of the qualifications at the time of appointment.

Document requirements

• Cover Letter

• Curriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).

• Statement of Research (Optional)

• Statement of Teaching (Optional)

• Statement of Contributions to Diversity - Please see the following page for more details: Contributions to Diversity Statement
  (Optional)

• Misc / Additional (Optional)

Reference requirements

• 2 required (contact information only)

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

San Francisco, CA