Senior Molecular Biologist - MLC 2389

View Vacancy -- Senior Molecular Biologist - MLC 2389
Open Date
11/04/2024, 00:00
Close Date
19/05/2024, 23:55
Research Institute 1  
MRC Mary Lyon Centre
Research Institute / Unit Information 1  
The Mary Lyon Centre at MRC Harwell (MLC) is located in an expanding science and innovation campus in Oxfordshire and is an internationally renowned centre at the forefront of genetics research.  As the hub of the new National Mouse Genetics Network, the specialist facilities and capabilities of the MLC support a number of research groups across the UK to accelerate our understanding of human diseases, such as cancer, developmental disorders and neurodegeneration.
UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org
Band 1  
MRC - 3
Location 1  
Harwell Campus, Oxfordshire
Salary 1  
£48,802–£56,817 per annum, dependent on skills and experience
Contract Type 1  
Permanent
Job Type 1  
Technical & Scientific Professionals
Full Time / Part Time 1  
Full Time
Job Description 1  

Overall Purpose:

The Mary Lyon Centre at the Medical Research Council Harwell (MLC) is recruiting a Senior Molecular Biologist for its Genome Engineering Service and to work in its collaborative programme for development of genome engineering technologies. The successful candidate will work within the Molecular and Cellular Biology (MCB) group and in close collaboration with the Genotyping core facility. Their activity will span genome editing of the mouse genome and validation of engineered alleles. 

The available post is based within established laboratories that have significant existing expertise in genome engineering in the generation and quality control of engineered mouse alleles. The successful candidate will work as part of a team and will be responsible for the design and validation of mouse models. They will advise Genome Engineering Service users. They will design genetically altered alleles, editing reagents and molecular assays for model characterisation. They will work collaboratively within the MCB team and with the MLC groups responsible for mouse production, breeding and embryo manipulation. They will scan the literature to keep up to date with genome-engineering developments and review the data for validation of new alleles. The candidate will also analyse production data to improve lab processes and will present findings in publications. 

An understanding of gene structure and expertise in standard molecular biology techniques (PCR, sequencing) are essential. Previous experience in the generation of genetically altered models (in vitro or in vivo) is required. Specialist training in genome engineering of mouse models can be provided. 

Main Duties/Key Responsibilities:

• Design and validation of mouse models by genome editing or homologous recombination
• Liaison with Genome Editing and Engineering Service users
• Coordination of molecular biology tasks in the MCB team and collaboration with other teams in the Mary Lyon Centre
• Review of data and production processes
• Development of new genome-engineering technologies
• Monitoring of current literature on genome engineering and updating the team on recent developments
• Dissemination of knowledge in genome engineering, taking part in writing publications and teaching at specialist workshops

Working Relationships:

• Design and validate genome-engineered alleles for the generation of models, working as part of a team with the other Molecular and Cellular Biology (MCB) team members, including direct reports, and reporting to the Head of MCB
• Work with scientists in the various research groups, to help design alleles for new mouse models
• Interface with the senior team of the Mary Lyon Centre, including the Director and Heads of Departments, to deliver key programmes and services 

Additional Information:

Some flexible working patterns and paid weekend work may be required at the discretion of the supervisor.

Person Specification 1  

Education/Qualifications/Training Required:

Essential:

• PhD and further experience in Biological Sciences, or equivalent, involving the use of molecular biology and genome engineering or editing
• Understanding of gene structure/function

Previous Work Experience Required:

Essential:

• Generation of genetically altered models
• Extensive use of PCR-based techniques
• Previous experience in genotyping 

Desirable:

• Experience of Sanger sequencing or digital PCR
• Evidence of quality- and customer-focused work
• Generation of genetically altered animals

Knowledge and Experience:

Essential:

• Experience of several of the following Molecular and Cellular Biology techniques: gene targeting, genome editing, PCR, Sanger sequencing analysis, ddPCR,
• Computer literacy is essential for the recording and communication of results 

Desirable:

• Working and adhering to standard operating procedures and experience of process analysis and refinement
• Experience in service provision

Personal skills/Behaviours/Qualities:

Essential:

• Organised and hard-working, with a strong eye for detail
• Able to provide leadership and work well as part of a team 

Desirable:

• Able to communicate clearly and concisely with a variety of scientists at all levels (from principal investigator to research assistants and animal technicians)

Further Information 1  

Equality & Diversity:

The MRC values the diverse skills and experience of its employees and is committed to achieving equality of treatment for all.  Our objectives are that all individuals shall have equal opportunities for employment and advancement on the basis of their skills, aptitudes and abilities.  The MRC is committed to the engagement and retention of the best possible talent and to creating an environment that encourages excellence in scientific research through good equality and diversity leadership and management. 

Corporate/Local Responsibilities & Requirements:

The post-holder must at all times carry out their responsibilities with due regard to the MRC’s:

• Code of Conduct
• Equality and Diversity policy
• Health and Safety policy
• Data Protection and Security policy 

All employees are required to act professionally, cooperatively and flexibly in line with the requirements of the post and the MRC.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.  The role holder will be required to have the appropriate level of security screening/vetting required for the role.  UKRI reserves the right to run or re-run security clearance as required during the course of employment.