Research Technician

We are seeking an enthusiastic Research Technician to work within a vibrant research team headed by Professor David Hodson at the Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) on studies related to type 1 diabetes (https://www.rdm.ox.ac.uk/people/david-hodson). 

The postholder will contribute to a Steve Morgan Foundation Type 1 Diabetes Grand Challenge, which is led by Oxford together with partners at the University of Birmingham and FMP Leibniz Berlin. The overarching aims of the Grand Challenge are to: 1) produce better functioning stem cell-derived beta cells to ensure long-lasting insulin-independence in people living with type 1 diabetes (T1D); 2) precision deliver therapy to the pancreatic beta cell surface that can fend off immune attack in the early stages of T1D; and 3) coax alpha cells, which survive immune destruction during T1D, to convert into insulin-positive cells to provide a new supply of beta cells without the need for transplantation. To allow this, we will target two surface receptors, which are highly expressed by alpha cells and beta cells. The major goal is to help improve stem cell-derived beta cell survival and function, allow immunotherapy to work better for longer with fewer side effects, and provide more evidence that endogenous beta cells can be regenerated, together making beta cell replacement a possibility for more people living with T1D.

Although full training will be given in a variety of techniques, the person appointed will be expected to work independently on most tasks or in collaboration with the support of colleagues. Methods will include the preparation and analysis of samples for hormone secretion, RNA extraction, PCR, cloning and optical imaging.  

Previous experience of working in a research environment, good time management and communication skills are essential for the role. Applicants will need to be able to communicate clearly within a multi-disciplinary team and have basic knowledge of biochemistry and metabolism.,

The position, funded by a Steve Morgan Foundation Type 1 Diabetes Grand Challenge, is full time and fixed term until 28th February 2029. The position will be based at OCDEM, Churchill Hospital, Headington, Oxford.

For informal enquiries, please contact Supprina Thebe at [email protected]. Please quote reference 172063 on all correspondence. As part of your formal online application, you will be required to upload a CV and supporting statement. Only applications received before midday on 30/04/2024 can be considered. Interviews are scheduled for 21/05/2024.