Research Associate / Senior Research Associate

We are seeking a Post-Doctoral Research Associate/Senior Research Associate (depending on experience) to perform laboratory-based snakebite envenoming (SBE) research in the Berger-Schaffitzel lab at the University of Bristol. The post-holder will use state-of-the-art protein engineering and display technology to generate high-affinity nanobodies against diverse toxins from snake venoms. These will be selected to neutralise the pathogenic function of toxins, for their use as antivenom.

The post-holder will benefit from the cutting-edge molecular biology, protein biochemistry, synthetic biology, structural biology and biophysics expertise and facilities in Bristol, capitalize on our eukaryotic expression, nanobody and Ribosome Display platforms, and synergize with our academic collaborators. Bristol offers state-of-the-art facilities for protein expression; access to modern biophysical instrumentation (surface plasmon resonance, dynamic light scattering, isothermal calorimetry, CD and fluorescence spectrometers) and cryo-EM is provided. Importantly, the post-holder will be member of and thus have access to equipment and facilities the Max-Planck Centre for Minimal Biology (https://maxplanck-minimalbiology.bristol.ac.uk/).

This UKRI funded project is a collaboration with Professor Nicholas Casewell at the Liverpool School of Tropical Medicine, who is a leading expert in venom analysis (using transcriptomics and proteomics approaches) and snakebite envenoming treatments.

The post-holder will:

• Work collaboratively on an original laboratory-based research project.
• Contribute to the design and development of the project (guidance will be given as to the direction of the research and the techniques used).
• Record accurately and clearly all results obtained at highest standard.
• Communicate the results of the project at regular internal laboratory meetings, meetings with the collaboration partners, and at appropriate scientific conferences.
• Contribute to the writing of research papers for publication in peer-reviewed journals.
• Manage and record all materials and results obtained or created during the course of the work.
• Assist in the day-to-day running of the shared research laboratory.
• Assist in the supervision of Ph.D. and B.Sc. students.

• You should hold, or expect to hold shortly, a PhD in Biochemistry, Biophysics or a related subject.
• Working experience with antibody libraries (or similar) and display techniques, molecular biology techniques, protein expression and protein purification techniques, biochemical and biophysical analysis.
• Keen interest in scientific questions under investigation in the lab coupled with a desire to learn/advance skills in new techniques.
• A published track record (including in press / in revision) of research productivity at a level that is appropriate for your current career stage.
• Willingness to travel occasionally and have flexible working practice.
• Possess good time management skills and the ability to prioritise and work independently and as part of a busy and vibrant team.
• Good communication skills, including excellent written and oral presentation skills in English.

For informal enquiries, please contact: Professor Christiane Berger-Schaffitzel

[email protected]  / +44 117 3941869

We recently launched our strategy  to 2030 tying together our mission, vision and values.

The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in an inclusive working environment where all colleagues can thrive and reach their full potential. We want to attract, develop, and retain individuals with different experiences, backgrounds and perspectives – particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution.

We are seeking a Post-Doctoral Research Associate/Senior Research Associate (depending on experience) to perform laboratory-based snakebite envenoming (SBE) research in the Berger-Schaffitzel lab at the University of Bristol. The post-holder will use state-of-the-art protein engineering and display technology to generate high-affinity nanobodies against diverse toxins from snake venoms. These will be selected to neutralise the pathogenic function of toxins, for their use as antivenom.

The post-holder will benefit from the cutting-edge molecular biology, protein biochemistry, synthetic biology, structural biology and biophysics expertise and facilities in Bristol, capitalize on our eukaryotic expression, nanobody and Ribosome Display platforms, and synergize with our academic collaborators. Bristol offers state-of-the-art facilities for protein expression; access to modern biophysical instrumentation (surface plasmon resonance, dynamic light scattering, isothermal calorimetry, CD and fluorescence spectrometers) and cryo-EM is provided. Importantly, the post-holder will be member of and thus have access to equipment and facilities the Max-Planck Centre for Minimal Biology (https://maxplanck-minimalbiology.bristol.ac.uk/).

This UKRI funded project is a collaboration with Professor Nicholas Casewell at the Liverpool School of Tropical Medicine, who is a leading expert in venom analysis (using transcriptomics and proteomics approaches) and snakebite envenoming treatments.

The post-holder will:

• Work collaboratively on an original laboratory-based research project.
• Contribute to the design and development of the project (guidance will be given as to the direction of the research and the techniques used).
• Record accurately and clearly all results obtained at highest standard.
• Communicate the results of the project at regular internal laboratory meetings, meetings with the collaboration partners, and at appropriate scientific conferences.
• Contribute to the writing of research papers for publication in peer-reviewed journals.
• Manage and record all materials and results obtained or created during the course of the work.
• Assist in the day-to-day running of the shared research laboratory.
• Assist in the supervision of Ph.D. and B.Sc. students.

• You should hold, or expect to hold shortly, a PhD in Biochemistry, Biophysics or a related subject.
• Working experience with antibody libraries (or similar) and display techniques, molecular biology techniques, protein expression and protein purification techniques, biochemical and biophysical analysis.
• Keen interest in scientific questions under investigation in the lab coupled with a desire to learn/advance skills in new techniques.
• A published track record (including in press / in revision) of research productivity at a level that is appropriate for your current career stage.
• Willingness to travel occasionally and have flexible working practice.
• Possess good time management skills and the ability to prioritise and work independently and as part of a busy and vibrant team.
• Good communication skills, including excellent written and oral presentation skills in English.

For informal enquiries, please contact: Professor Christiane Berger-Schaffitzel

[email protected]  / +44 117 3941869

We recently launched our strategy  to 2030 tying together our mission, vision and values.

The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in an inclusive working environment where all colleagues can thrive and reach their full potential. We want to attract, develop, and retain individuals with different experiences, backgrounds and perspectives – particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution.