We are seeking to appoint a Research Assistant in Assay Development & High-Throughput Screening to join our Chemical Biology research group at the Centre for Medicines Discovery, Nuffield Department of Medicine.
You will be responsible for performing and developing cellular assays and model systems to study the function of disease-relevant genes and determine the cellular effects of small molecule probes using a variety of functional assays. You will be tasked with assisting a multidisciplinary team in follow-up studies and characterization of novel chemical probes for drug target validation in cancer and inflammatory disease. Throughout this role, you will be performing cell assays using different readouts (e.g. CellTiter Glo, colony formation assays) in different plate formats. Finally, you will also be responsible for performing meticulous documentation of experimental results and procedures, and providing information for publication of the results.
It is essential that you are hold a first degree in biology or biotechnology, together with experience in designing and cloning CRISPR and shRNA constructs. You will also have experience in designing and developing cellular reporter (e.g. luciferase-based) or cell target engagement assays (e.g. CETSA, NanoBRET). You should have basic general lab practice (cell biology, PCR, microscopy, lab instrumentation) and the ability to work as part of a team and communicate/collaborate with colleagues orally and in writing and assist in supervising students.
Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.
This position is offered full time on a fixed term contract until 30 April 2025 and is funded by the IMI.
Only applications received before 12 midday on Friday 5 January 2024 will be considered. Please quote 169057 on all correspondence.
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