Post Doc - Cardiac Microvascular Disease

80%-100%, Zurich, fixed-term

Cardiovascular disease (CVD) is the leading cause of terminal illness worldwide. An aging population, improper nutrition, and a sedentary lifestyle combined with poor prevention render CVD a leading threat to human health worldwide. In front of this challenge, the Swiss Federal Institute of Technology (ETH Zurich) initiated an interdisciplinary program to generate innovative technological solutions to improve the diagnosis and treatment of cardiovascular disease. 

The TCT Lab under the leadership of Prof. Volkmar Falk (Medical Director of the German Heart Center Berlin) connects ETH Zurich’s world-class engineering knowhow with today`s leading cardiovascular institution in Europe (German Heart Center Berlin) to enable the development of next-generation medical devices as well as new diagnostic and therapeutic strategies.

Project background

Despite significant progress treatment of acute myocardial infarction (MI), underlying or subsequent microvascular issues like MINOCA or Post-STEMI MVO remain a poorly defined clinical condition. Yet they affect up to 30% of all MI cases. The absence of early diagnostic methods and tailored therapies for MINOCA and Post-STEMI MVO contributes greatly to elevated mortality rates among affected patients.

Recently, our group has developed a porcine model of micro-thrombosis (microembolisation) induced MINOCA and Post-STEMI MVO.

Job description

We are seeking a highly motivated individual for a dynamic position in biomedical translational research, with a focus on cardiovascular microcirculation. As a key member of our multi-disciplinary team, comprised of medical and veterinary doctors, engineers, and molecular biologists, your primary responsibilities will include establishing a comprehensive OMICS pipeline encompassing proteomics, transcriptomics, and metabolomics. The role will involve outsourcing histology and immunohistochemistry analysis, organization and coordination of animal experiments, as well as efficient sample collection and distribution. Additionally, you will be tasked with project oversight, ensuring the seamless execution of research objectives. A critical aspect of this position involves the development and optimization of thrombolysis assays. Your contribution will extend beyond the laboratory as you take charge of writing publications, abstracts, and grant applications. This challenging and rewarding role offers a unique opportunity to contribute to cutting-edge research at the intersection of multiple scientific disciplines. The position is foreseen for 1 year with a possibility of further extension.

Your profile

You have:

• a PhD in molecular biology, immunology, physiology, biomedical engineering, material science, or bioinformatics.
• Experience in cardiovascular research and publications are advantageous, they are not mandatory.
• Key attributes including analytical thinking, effective communication, teamwork, motivation, assertiveness, and a solution-oriented approach. 

Your workplace

Your workplace

We offer

ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.

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We value diversity

In line with

our values

, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our

Equal Opportunities and Diversity website

to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So are we.

We look forward to receiving your online application with the following documents:

• CV
• Motivation Letter
• Publication List

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Further information about the TCT Lab can be found on our website . Questions regarding the position should be directed to Dr. Cesarovic, email [email protected] (no applications).

About ETH Zürich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.