The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel across 6 different locations. Be part of our future!
The research group led by Dr. Prof. Beltra is currently seeking a highly motivated Ph.D. student with a strong interest in conducting high level research in the fields of T-cell immunobiology and cancer immunotherapy. This position will be based in the Department of Biomedicine (https://biomedizin.unibas.ch/en/) in Basel, Switzerland - one of the world's leading locations for life sciences, home to several companies and institutions.
Prof. Beltra's group is studying the factors governing T-cell differentiation programs in settings of viral infections and cancers. Notably, we are particularly interested in identifying new pathways regulating the process of CD8 T cell exhaustion, an hypofunctional program acquired by CD8 T cells exposed to persistent inflammation and antigenic stimulation. Indeed, CD8 T cell exhaustion represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking. By exploring the intimate mechanisms regulating CD8 T cell exhaustion, our group aims to identify innovative opportunities to reverse this process and unleash the full potential of current cancer immunotherapies (e.g. PD-1-based therapy). To this end, we have developed relevant murine models for the study of CD8 T cell-exhaustion and are leveraging cutting-edge technologies (single cell omics, ATACseq) and innovative immunological and genetic perturbation tools (Retroviruses, CRISPR), to identify and characterize new pathways of interest for a better therapeutic manipulation of exhausted CD8 T cells. Collectively, our group aims to lay the foundation for advancing next-generation cancer immunotherapies.
Similar Positions
-
Ph.D. Position In Immune Cell Biology, University of Fribourg, Section of Medicine, Switzerland, 12 days ago
18 Apr 2024 Job Information Organisation/Company University of Fribourg, Section of Medicine Department Medicine Section, Dept. OMI Research Field Medical sciences » Health sciences Researcher Pro...
-
Scientific Research Technician Cancer Stem Cells (Veterinary Faculty), AcademicTransfer, Netherlands, about 17 hours ago
We are looking for a scientific research technician who will be providing technical support to our research team. You will be working closely with 2 PhD students and master students. You will be e...
-
Scientific Research Technician Cancer Stem Cells (Veterinary Faculty), AcademicTransfer, Netherlands, about 15 hours ago
We are looking for a scientific research technician who will be providing technical support to our research team. You will be working closely with 2 PhD candidates and with Master's students. You ...
-
Qc Associate Ii Gmp Manufacturing, City of Hope, United States, about 15 hours ago
Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope , where we're changing lives and making a real difference in the fight against cancer, diabetes, and...
-
Scientist (M/F/D) “Regulatory Affairs Cell Line Banking And Customer Support”, Leibniz, Germany, about 13 hours ago
Scientist (m/f/d) “Regulatory Affairs Cell Line Banking and Customer Support” at the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany, in th...
-
Research Associate Ii T Cell Therapeutics Research Laboratory, City of Hope, United States, about 15 hours ago
Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions. Join the forefront of groundbreaking research at the Beckman Research Instit...