Research Specialist in molecular diagnostics

The Department of Laboratory Medicine consists of seven divisions and is active in many areas of laboratory medicine. The department is engaged in advanced basic scientific, clinical and epidemiological research. It is one of the largest educational institutions at Karolinska Institutet.

The EL Andaloussi lab's focus is on developing technologies to exploit the medical applications of extracellular vesicles (EVs). This includes engineering EVs for therapeutic drug delivery and analyzing EVs in blood plasma to detect disease. EVs represent a unique opportunity for molecular diagnostics as they are released by all cells and carry the contents and express surface proteins of their cell of origin. Our research program involves developing new and innovative technologies to separate and analyze plasma-borne EVs. To achieve this, we optimize methods to enrich EVs from small blood volumes and to purify defined populations derived from specific cell types. To analyze the diagnostic information in EVs, we focus on multi-parameter methods such as nucleic acid sequencing and proteomics. Thus, our research platform offers a unique opportunity to discover clinically relevant methods for EV-based molecular diagnostics.

As a research specialist, you will coordinate the development and clinical implementation of methods for extracellular vesicle purification and analysis of their content. Your tasks will be to assist in the preparation of ethical approvals, address regulatory barriers and assist in the optimization and characterization of the methods developed for EV enrichment. Most of the work will be performed with clinical samples obtained through various collaborations with Karolinska University Hospital. The projects will be highly innovative and require up-to-date knowledge in the field as well as an excellent ability to integrate and apply advanced technologies to develop innovative technical methods. In your role as a researcher, you will work hands-on in the laboratory, interpret and write legal documentation, participate in the conception and design of new projects and take on supervisory responsibilities.

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

It is particularly meritorious that the applicant has shown

• Experience in the development and optimization of tests
• Experience in IP generation and protection
• Great interpersonal skills, extensive leadership experience and a positive attitude
• Knowledge of medical device regulation and collaboration between academia and industry

It is meritorious that the applicant has shown

• Experience in coordinating work in multi-centered projects
• Skills in the Linux environment
• Extensive experience in protein biochemistry and cell biology.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg, Huddinge

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest 1 March.

The application must be submitted through the Varbi recruitment system.