Research Engineer in NMR-Based Structural

The University of Gothenburg tackles society’s challenges with diverse knowledge. 53 500 students and 6 500 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy. 

The group of Björn Burmann uses state of the art NMR-spectroscopy to study large molecular complexes underlying basic cellular functions at the atomic level in combination with other structural biology methods and biophysical characterization. Björn Burmann’s group investigates macromolecular protein machines underlying essential cellular functions, e.g. protein quality control and their effect on misfolding- and aggregation-prone proteins underlying several different diseases, through biophysical and structural biology approaches e.g. high-resolution Nuclear Magnetic Resonance (NMR). Results of previous studies into molecular chaperones and functional mechanism of proteases at the atomic level have been published in top journals. More details on our research can be found at: www.wcmtm.gu.se/research-groups/burmann. Structural characterization and biophysical analysis of transcription associated processes.

The research project aims at advancing the molecular understanding of the function and regulation of bacterial homo-oligomeric serine proteases by advanced NMR-spectroscopy. Malfunction of these fundamental proteases leads to the accumulation of misfolded proteins and thus provide the foundation for cell death in bacteria. Specifically, you will study (1) the molecular mechanisms by which the bacterial DegP protease is regulated and activated (2) how it recognizes and subsequently cleaves misfolded protein substrates, and (3) how the DegP is regulated by and interacting with auxiliary factors. To achieve this goal, you will use a plethora of techniques ranging from basic biochemistry to advanced structural biology methods and biophysical characterization. Methods in microbiology, molecular biology, bioinformatics and biochemistry will also be used. We are looking for a colleague, that is highly motivated, scientifically independent, and creative, and capable of contributing to a team environment.

An advanced degree in a relevant field such as Molecular Biology, Biochemistry, Biophysics, Structural Biology or related fields is expected. Previous work on related protein systems will be considered favorable. The successful candidate should have a strong background in biochemistry, biophysics, and NMR spectroscopy. Previous work related to serine proteases, e.g. expression and purification and/or functional characterization for structural studies, will be considered an advantage. Possessing detailed experience in the following techniques is considered mandatory:

• Knowledge in recombinant protein expression and purification of relevant proteins, such as bacterial DegP or DegQ.
• Expert knowledge in solution NMR methods (e.g. assignment, protein dynamics, data analysis)
• Expert knowledge in sample preparation (isotope labelling, methyl-labelling)
• Detailed knowledge in additional biophysical and structural biology techniques (ITC, BLI, SEC-MALLS, EM, X-Ray)
• Documented knowledge in automated data procession and analysis

Furthermore, a genuine interest in structure and dynamics or protein function is required. Co-Authorship in high impact journals such as Nature, Science or Science Advances is considered favorable.

The employment is a fixed term during 6 months, fulltime at the Department of Chemistry and Molecular Biology

Regarding the position, please contact Björn Burmann, Associate Professor, +46(0)31 786 3923 [email protected]

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In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application 2022-02-03. Your applications must include: 

The application shall include:

Cover letter with an explanation of why you apply for the position

CV including scientific publications
Copy of exam certificate
Two referees (name, telephone no, relation)

Closing date: 2022-02-03  

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

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