Research Assistant ADME

Published: 2022-11-20

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 54,000 students, more than 7,500 employees and a turnover of around SEK 8 billion.

The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) is located at the Department of Pharmacy, Uppsala University. The primary aim of UDOPP is to perform in vitro ADME (Absorption, Distribution, Metabolism and Excretion) investigations of hit collections and compound series during lead optimization in collaboration with academic research groups. The platform also performs preclinical characterization of lead and candidate drug compounds and bioanalytical services. The platform was formed in 2010 and is supported by a research group performing innovative research in the ADME and drug delivery field.

UDOPP is part of the Innovative Medicine Initiative (IMI) Conception consortium. UDOPP, the ENABLE2 platform, and as ADME of Therapeutics facility, the SciLifeLab Drug Discovery and Development platform (SciLifeLab DDD). For more information, please visit the following respective homepages at: Conception

The Swedish Government has authorized the Swedish Research Council (VR) to support the national research program ENABLE2. The aim of ENABLE2 is to establish a national drug discovery platform in Sweden for testing and optimizing molecules, which have the potential to become future drug candidates capable of treating resistant gram-negative infections (Enable ). The ADMEoT (UDOPP) team is responsible for all in vitro ADME investigations within the ENABLE2 platform.

We are now recruiting a highly motivated and flexible in vitro ADME research assistant to expand our capacity. The position will be located at the ADMEoT facility (SciLifeLab DDD) at the department of Pharmacy at Uppsala University. Further information about the department and the research groups can be found at Farmaci

Duties: The candidate will perform daily experimental work with physicochemical, in vitro ADME and cell-based assays for small molecules and peptides. The successful candidate will analyze in vitro samples using the LC-MS/MS and report the results to the ENABLE2 project teams. The candidate will also work as an ADME project team member within the ENABLE2 platform.

Desired qualifications: The successful candidate should have a master's degree in biology, biochemistry, pharmacy or similar. The candidate should have 5 years of experience from the biotech/pharmaceutical industry and worked as a project member in preclinical drug development projects. Previous experience within infection and antibacterial drug development is an advantage.

The right applicant has good laboratory skills, including the ability to plan, design and perform experiments, analyze the data and report in vitro ADME results according to the regulatory agencies’ recommendations. Practical experience with the Caco2 and MDCK cells permeability assays and interpretation of the results is crucial.

Previous experience with outsourcing of the in vitro ADME assays and experience with analysis, especially with LC-MS/MS, are an advantage.

The right applicant should have good laboratory skills, including the ability to plan and conduct experiments, analyze data and report in vitro ADME results as recommended by regulatory authorities.

The ideal candidate is flexible, motivated, has good problem-solving ability and can deliver on short timelines. Good social skills, good co-operation skills and ability to present within interdisciplinary teams in English are required.

For further information about the position, please contact: Docent Pawel Baranczewski, [email protected] phone +46 (0) 707467894 or +46 (0) 18 4714967 (office).

Please submit your application by 6 December 2022, UFV-PA 2022/4304.

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Submit your application through Uppsala University's recruitment system.

Placement: Department of Pharmacy

Type of employment: Full time , Temporary position longer than 6 months

Number of positions: 1

Working hours: 100%

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative: Seko Universitetsklubben [email protected]
ST/TCO [email protected]
Saco-rådet [email protected]

Number of reference: UFV-PA 2022/4304

Last application date: 2022-12-06

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