Postdoctoral Researcher in embryonic epigenetics

We are looking for an ambitious PhD graduate with advanced skills in epigenomics and single cell profiling to perform cutting-edge research within two engaging and international research groups. This is an opportunity to contribute to high-quality research on an internationally competitive level at Karolinska Institutet and Scilifelab. We are looking for a highly motivated individual, who excelled during her/his doctoral studies, has substantial experience in developing single cell-based technologies, and strong documented interest in epigenetics.

As a postdoc in this project, you will be part of KIRI, the Karolinska Institutet Research Incubator, a unique initiative at KI to build a community for interdisciplinary research and breakthrough discoveries. You will have access to two PI:s that you can meet and interact with to facilitate the research process and increase the synergetic effects. As part of KIRI, you will also have the opportunity to meet other KIRI postdocs conducting state-of-the-art research, present your work at scientific events, and take part in KIRI activities. Read more about KIRI here. 

Fredrik Lanner is an expert in human embryology, stem cell and single cellbiology.The Lanner lab develops pluripotent stem cell based cellular therapies and explores the mechanisms that control early human embryo development and pluripotency. The group is a mix of medical and basic-science oriented members including PhD students, postdocs, a senior bioinformatician and a lab manager, providing an inspiring environment to support the KIRI postdoc. The lab is fully equipped for innovative research in stem cell and human embryo research including embryo-manipulation equipment and it is integrated with the Reproduction medicine unit, within Karolinska University hospital.

Simon Elsässer has extensive experience in molecular biology, chromatin biochemistry, epigenomics and bioinformatics. The Elsässer group is an international and multicultural research group that focuses on applying new synthetic and chemical biology methods to understand chromatin structure and function. The group is located at the Science for Life Laboratory in Stockholm and includes senior and junior researchers, bioinformaticians, administrators, PhD students and undergraduate trainees.

The proposed project provides a fantastic training opportunity for the KIRI postdoc, applying the most advanced embryo models available today with state of the art epigenomics technologies, generating a comprehensive epigenomic atlas of early human embryonic lineages and dissecting the network of transcription factors and epigenetic regulators defining early cell fates.

The successful candidate will be supervised jointly by the two PIs and be part of both research group activities while moving research as needed between the two laboratories. The ability to work independently and as part of a team is essential for this position.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Essential:

• Proven experience in developing epigenetic methods and experience with naive pluripotent stem cells
• Proven experience in developing cell-based techniques to profile human embryos and stem cell models
• Good communication skills in English
• Independent working skills, teamwork spirit and willingness to help PhD/master students

Desired:

• Strong expertise in microscopy 
• Proficiency in scientific programming and bioinformatic analysis

You should be highly motivated and interested in developing and performing epigenetic analysis of early human embryos and stem cell models. It is important that you are independent, take your own initiative and have very good cooperation skills. Furthermore, it is important that you are performance-oriented. We value personal qualities in the selection of candidates.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Scilifelab, Solna and Flemmingsberg

Choose to work at KI – Ten reasons why

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest February 29th 2024.

The application is to be submitted through the Varbi recruitment system.