The spatial distribution of membrane proteins is increasingly thought to regulate receptor signaling, and there is growing recognition that the ability to detect and visualize protein distributions at this scale is a capability for next generation biological research and therapeutics. Existing techniques for detecting nanoscale protein distributions such as super resolution microscopy are often limited by throughput, and are not well suited for large-scale data collection or characterization of cell populations. The Högberg group is interested in exploring molecular probing techniques as an alternative to super resolution microscopy for gathering nanoscale data on the distribution of proteins on cell surfaces. Such an approach could enable ensemble characterization of populations of cells instead of individual cells for better characterization of cell biology and eventually could be used in clinical diagnostics to distinguish diseased cells from healthy ones. To achieve such a feat, we are developing the basic molecular methods using DNA nanotechnology. Due to its capacity for information storage, manipulation, and transfer, DNA is an ideal tool for nanoscale probing. Developing, deploying, and analyzing DNA probes will require a combination of physical chemistry, cell biology, and computational processing.
The Division of Biomaterials and Regenerative medicine focuses on developing new materials for biology and medicine and is a mixture of nanotechnology, cell biology, and polymer science.
We seek a postdoc who will develop both the physical and computational processing stages of DNA nanotechnology-based probing methods for cell biology. The project will be carried out in a nucleic acid laboratory, cell culture facility, and chemical synthesis laboratory as well as in silico. The position will involve publishing of results in leading academic journals.
A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.
Candidates should have a Ph.D. in Chemical/Biomedical Engineering or Polymer Chemistry/Physics. We are seeking an outstanding candidate with excellent research and publication record who has a strong background in the following areas: silica-based surface chemistry, membrane/cell biology, image processing, DNA nanotechnology. The candidate must be confident in writing his/her own image processing and data analysis programs in Python and be familiar with numerical methods, clustering analysis, and stochastic simulation. The candidate must have demonstrated experience in laboratory chemistry/biochemistry of nucleic acids and/or DNA nanotechnology. Experience with mammalian cell culture is a plus. We are looking for a strongly motivated person who is prepared to work independently. Excellent oral and written English is a must.
An employment application must contain the following documents in English or Swedish:
The application is to be submitted through the MyNetwork recruitment system. The position is for one year with possibility of extension.
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