The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.
A doctoral position is an available doctoral education project to which a PhD student is to be recruited. After the selection process the process for admission to doctoral education will commence. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board.
For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral .
The position is placed in the research group of Olov Andersson at the Department of Cell and Molecular Biology, Karolinska Institutet. Bridging developmental biology and drug discovery, we use the zebrafish model to elucidate organogenesis and related mechanisms of disease. We are currently focusing on pancreatic beta-cell regeneration.
The doctoral education project and the duties of the student
We are seeking a highly motivated and enthusiastic doctoral student to study regeneration of pancreatic beta-cells as an approach to curing diabetes. The lab uses chemical screening techniques in zebrafish larvae to identify and characterize compounds, signalling pathways and cellular mechanisms that can promote β-cell regeneration. We then validate our initial findings by changing the stage (larvae vs adult), approach (chemical vs genetic), and model organism (zebrafish vs mouse). For examples of how the research can be conducted, see:
Lu et al., The EMBO Journal 2016, Aug 11:
Andersson et al., Cell Metabolism 2012, Jun 6;15(6):885-94:
The zebrafish are amenable to efficient transgenesis and high-resolution imaging. We will make use of these properties and generate transgenic zebrafish for analysis of phenotypes at the cellular level.
Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:
General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:
Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.
For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education
Other formal entry requirements, beside the above, that an applicant must have to be considered for this project
Experience in cell and molecular biology methods and experience of working with diabetic animals.
Skills and personal qualities
We expect you to be a very creative person with excellent communication skills and abilities to collaborate and work in a highly dynamic international research team. You have good knowledge of experimental techniques within cell and molecular biology, as well as interest in interdisciplinary work integrating pharmacology and developmental biology using diabetic zebrafish/mouse models.
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject
The qualifications of the applicants will be evaluated on an overall basis.
Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.
An application must contain the following documents in Swedish or English:
- A personal letter and curriculum vitae
- A copy of degree certificates and associated certificates
- A copy of degree projects and any previous publications
The application is to be submitted through the MyNetwork recruitment system.
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