Researcher at the Department of Biomedicine

27 May 2024
Job Information

Organisation/Company

University of Bergen

Department

Department of Biomedicine

Research Field

Biological sciences
Medical sciences

Researcher Profile

Recognised Researcher (R2)

Country

Norway

Application Deadline

17 Jun 2024 - 23:59 (Europe/Oslo)

Type of Contract

Permanent

Job Status

Full-time

Hours Per Week

37,5

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description
UiB - Knowledge that shapes society

Through robust and close interaction with the world around us – globally, nationally and locally – we shall be instrumental in building a society based on knowledge, skills and attitudes.

Do you want to take part in shaping the future?

Researcher

At the Faculty of Medicine, Department of Biomedicine, a full-time permanent position as researcher is available. The position is associated with the large, interdisciplinary research project "Hub Molecules of Life" (HubMOL), which is jointly financed by the Research Council of Norway (RCN) and the University of Bergen. The position has a temporary financing from RCN for 36 months. The startup date will be as soon as possible.

About the project/work tasks:

In all living organisms, there is a subset of small coenzyme molecules that participate in thousands of biochemical reactions, thereby enabling and coordinating metabolism. In the course of evolution, the same molecules have attained more and more key roles as regulators of virtually all biological processes, often through posttranslational protein modifications. This is illustrated, for example, by the use of NAD in a multitude of metabolic reactions and at the same time as substrate for ADP-ribosylation and protein deacetylation. HubMOL aims to unravel the mechanistic principles of how these molecules of life interact to enable and control both metabolism and signaling. The project combines world-leading competences in synthetic and analytical chemistry, biochemistry, molecular genetics, bioinformatics and advanced technology development. Through their direct association with established medical research centers (NeuroSysMed with a focus on neurodegeneration, KG Jebsen Center on Parkinson's Disease), the core scientists will closely collaborate with clinicians to apply the findings from basic research to disease diagnostics and treatment.

HubMOL is an interdisciplinary, international project with partners in Norway, Austria and the USA. The successful candidate will work in the group of the project leader, Prof. Mathias Ziegler, at the Department of Biomedicine, who is leading studies on metabolism and signaling, closely collaborating with Prof. Ines Heiland, who is an expert in metabolic modeling. Active participation in and contribution to joint project meetings and workshops is expected.

The successful candidate is expected to lead this sub-project with diligence and a high level of independence, initiative and problem-solving capacity. The position will require being constantly updated with methodological developments and advances in the field. At the same time, this position will offer substantial opportunities for career development and growth. The candidate will work with state-of-the-art analytical instrumentation, generate extensive experimental data sets and analyze them using advanced bioinformatics methods.

The work tasks include to:

• Design cell culture experiments suitable for investigating mechanistic principles of how small molecules, such as NAD, CoA or FAD, control processes related to metabolism and signaling
• Develop targeted LC-MS-based methods for analyses of coenzyme metabolites and implement routines for highly accurate quantification in experimental and clinical samples.
• Design and conduct fluxomics experiments, including stable isotope labeling, to establish turnover of hub molecules, their derivatives and PTMs.

Qualifications and personal qualities:

• The applicant must hold a relevant Norwegian PhD or equivalent doctoral degree

• Documented broad knowledge of metabolic pathways, ideally, in coenzyme metabolism

• Proven competence and hands-on proficiency in LC-MS-based methods, ideally, for metabolomics and analyses of biological samples, in particular, Orbitrap and QQQ MS instrumentation

• Expertise in development of methodological approaches for targeted and untargeted LC-MS analyses of biological samples

• Experience with bioinformatics tools to process LC-MS data

• Track record of peer-reviewed publications in internationally renowned journals

Excellent verbal and written communication skills. Fluent verbal and written English language skills are a prerequisite.

The following skills would be advantageous:

• Familiarity with the use of stable isotope labeling in metabolomics
• Experience working with cell culture.
• An interest in metabolic modeling
• Experience in teaching at university level
• Demonstrated ability to work independently within an international environment.
• Proven problem-solving skills, collaborative nature, and adaptability across disciplines

We can offer:

• An excellent and ambitious work environment at the research front of translational metabolism and signaling.

• Salary NOK 624 500 (code 1109, pay grade 64), specialist NOK 646 000 (code 1109, pay grade 66) gross p.a. for a fulltime position. In the case of a highly qualified applicant, a higher salary may be considered.

• Enrolment in the Norwegian Public Service Pension Fund.

• Good welfare benefits .

Your application must include:

• A brief letter of application stating your motivation for this position, why you are applying and why this position is perfect for you

• An overview of your education and work experience (CV)

• Copies of diplomas and relevant certificates (applicants with education from other countries than Norway must enclose diplomas in both the original language and authorized translations)

• Publications and academic work (max 3 in PDF) and a list of these

• Your PhD thesis (in PDF)

• Two references (name and contact information)

It is very important that each of the scholarly works on which the committee should place special emphasis, is attached in its entirety.

The application and any attachments along with certified translations in English or another Scandinavian language must be uploaded to JobbNorge.

The following premise forms the basis for the post as research scientist:

• The researcher will be a member of the research group of which the topic/project belongs to

• The salary shall if possible be 100 % covered by external financing

• The researcher shall actively contribute to attract external funding to the research project, both for her/his own position and other positions, from the Research Council of Norway, EU and other sources

• The researcher is expected to have her/his research activity financed by the project of the researcher and the projects of the associated research group

• The Head of Department may allocate work for the Researcher related to specific research projects

• The researcher may participate in committee work and other administrative tasks within the University of Bergen

• The researcher has no teaching duties, but is expected to supervise master students and PhD candidates when this is a natural part of the research activity of the research group

• The researcher may apply for competence promotion according to the regulations for promotions 

• The basis for the position ceases if no further project funding and new law on state officials etc. on dismissal and preferential rights will be applied to permanent employees

General information:

Further information about the position can be obtained from: Professor Mathias Ziegler, phone: +4755584591 or e-mail: [email protected] .

University of Bergen must follow Norway’s export control regulations when processing applications for this position.

Diversity is a strength that enables us to solve our tasks even better. UiB therefore needs qualified employees regardless of gender, ethnicity, religion, worldview, disability, sexual orientation, gender identity, gender expression, and age.

The University of Bergen applies the principle of public access to information when recruiting staff for academic positions.

We encourage applicants with disabilities, immigrant backgrounds, or gaps in their CV to apply. By indicating such circumstances in your application, you may receive favourable consideration. We ensure that at least one qualified applicant from each of these groups is invited for an interview as part of our commitment to inclusivity and equal opportunity.For further information about the recruitment process, click here .

 

About The University of Bergen

The University of Bergen is a renowned educational and research institution, organised into seven faculties and approximately 54 institutes and academic centres. Campus is located in the centre of Bergen with university areas at Nygårdshøyden, Haukeland, Marineholmen, Møllendalsveien and Årstad. 

There are five departments and eight centres at Faculty of Medicine.

Read More about the facult y and departments .

 

Requirements

Research Field

Biological sciences

Education Level

PhD or equivalent

Research Field

Medical sciences

Education Level

PhD or equivalent

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

University of Bergen

Country

Norway

Geofield

Where to apply

Website

https://www.jobbnorge.no/en/available-jobs/job/263561/researcher-at-the-departm…

Contact

City

Bergen

Website

http://www.uib.no

Street

Jonas Lies vei 91

Postal Code

N-5021

STATUS: EXPIRED