PhD Research Fellow in DNA repair and telomere stability in cancer (ref 259850)

21 Mar 2024
Job Information

Organisation/Company

University of Oslo

Research Field

Medical sciences

Researcher Profile

First Stage Researcher (R1)

Country

Norway

Application Deadline

21 Apr 2024 - 23:00 (Europe/Oslo)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

37.5

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Development of cancer requires pre-cancerous cells to evolve ways to circumvent the limited replicative lifespan of human somatic cells. In up to 80–90% of cancers this is mediated by overexpression of the telomerase multiprotein-RNA complex, which elongates chromosomal ends using an RNA template.

Although targeting the telomerase pathway is a promising strategy for cancer treatment, to date, no pharmacological options for disrupting oncogenic telomerase activity have been approved for regulatory use, despite significant advancements in this field. However, we have recently demonstrated that deficiency specific DNA damage proteins leads to defects in RNA quality control, which affects the stability of the telomerase RNA-component, conferring telomere dysfunction and cellular growth arrest. The key knowledge need is to translate this finding into a therapeutic application.

For more information and how to apply: https://www.jobbnorge.no/en/available-jobs/job/259850/phd-research-fellow-in-dna-repair-and-telomere-stability-in-cancer

Requirements

Research Field

Medical sciences

Education Level

Master Degree or equivalent

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Institute of Clinical Medicine (Klinmed)

Country

Norway

Geofield

Where to apply

Website

https://www.jobbnorge.no/en/available-jobs/job/259850/phd-research-fellow-in-dn…

Contact

City

Oslo

Website

https://www.med.uio.no/klinmed/english/

Street

PO box 1072 Blindern

Postal Code

NO-0316

E-Mail

[email protected]

STATUS: EXPIRED