Senior postdoc at the assistant professor (UD) level – Therapeutic gene delivery

6 Feb 2024
Job Information

Organisation/Company

University Medical Center Utrecht (UMC Utrecht)

Research Field

Medical sciences

Researcher Profile

Recognised Researcher (R2)
Leading Researcher (R4)
Established Researcher (R3)

Country

Netherlands

Application Deadline

26 Feb 2024 - 22:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

We offer a position for a senior postdoc/assistant professor (UD) level in gene therapy within the UMC Utrecht. To this end, the assistant professor will work in a division overarching team that strives to accelerate clinical development gene therapies by focusing on one of the current main obstacles in this field: efficient delivery of gene products to the organs and cell types of interest. You will develop optimal viral delivery vectors. We are looking for a molecular biologist with knowledge and experience in viral vector development and production for in vivo delivery and efficacy. The project is funded by the Governmental Sector Money and aims to build an in-house gene therapy platform within UMC Utrecht, to support development of gene therapy. For this team, three new members are recruited to sdevelop both ex vivo and in vivo genetic therapies for early phase clinical trials (through the Innovation Center for Advanced Therapies (ICAT) and in vivo gene therapies through viral delivery (in the department of Translational Neurosciences) and non-viral delivery strategies for different gene-products (in the department of Metabolic Diseases in the Regenerative Medicine Center Utrecht (RMCU). Your role is to develop viral vector material, apply gene therapy in vivo (mostly in preclinical mouse models) and assess the delivery and efficacy in vivo.

Requirements
Specific Requirements

• A PhD in a relevant field (Biopharmaceutical, Biotechnology, Bioengineering, Virology, Cell Biology, Molecular Biology) and affinity with applied virology including viral vector development, production and delivery.
• An MSc in a relevant field with a minimum of 5 years relevant work experience with applied virology including gene therapy delivery.
• Knowledge in viral vector design and delivery, in designing minimal promoters for cell specific targeting, prime editing, scRNAseq, analytical characterization, and process development with hands-on experience in viral transductions, flow cytometry, and quantitative gene expression analyses (ddPCR, qPCR, RNAseq).
• Hands-on expertise of viral vector production (RV, LV and/or AAV using HEK293 cell line or other suspension cell lines) and experience with viral risk assessments, viral safety testing and control strategies.
• Experience with delivery of gene therapy in vivo.
• The candidate should be self-motivated, accountable, inquisitive, and have excellent organization and communication skills (written and verbal).
• Possess the ability to present technical information to both technical and non-technical audiences.
• Professional proficiency in English (written and spoken) is a requirement.
• Ability to think analytically, problem-solving skills, drive to succeed.
• You enjoy working in an innovation driven, highly collaborative and fast paced environment.
• You should be able to work independently as well as collaborate with other team members with interdisciplinary background and international environment; you have essential social skills for fruitful interactions.
• You must be available fulltime.

Additional Information
Benefits

The maximum salary for this position (36 - 36 hours) is € 6.156,00 gross per month based on full-time employment.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

Additional comments

Contact our colleague:
Marie Hagen
0887568805
[email protected]

Website for additional job details

https://www.academictransfer.com/337450/

Work Location(s)

Number of offers available

1

Company/Institute

UMC Utrecht

Country

Netherlands

City

Utrecht

Postal Code

3584CX

Street

Heidelberglaan 100

Geofield

Where to apply

Website

https://www.academictransfer.com/en/337450/senior-postdoc-at-the-assistant-prof…

Contact

City

Utrecht

Website

http://www.umcutrecht.nl/

Street

Heidelberglaan 100

Postal Code

3584 CX

STATUS: EXPIRED