A PhD fellowship in medicinal chemistry is available at the Department of Physics and Chemistry, University of Southern Denmark. The PhD project will be attached to ANFA (Anti-obesity effects of nutrients by hypothalamic fatty acid receptor activation), a project in collaboration with the University of Campinas, Brazil. The position is vacant from 1 June 2017 or as soon as possible thereafter. Application deadline: 1 May 2017.
The hypothalamus is a key regulator of metabolism, and hypothalamic inflammation has been linked to the development of obesity. The free fatty acid receptors FFA1 and FFA4 also control metabolism through regulation of various hormones, and both receptors are expressed in the brain. FFA1 is an established target for treatment of type 2 diabetes and has also been suggested as a target for treatment of pain and neurodegenerative diseases. FFA4 has anti-inflammatory and insulin sensitizing effects. This project aims to elucidate the effect of activation of FFA4 and FFA1 in the hypothalamus, especially with regard to appetite and obesity; to determine the ability of fatty acids in various forms, including as free fatty acids, triacylglycerides, and phospholipids, to reach the CNS after oral intake; and to investigate the ability of dietary fatty acids on various forms to counteract obesity through activation of hypothalamic FFA4 and FFA1.
The PhD study will to a large degree focus on organic synthesis and compound design, in particular development of specific receptor tool compounds with high blood-brain barrier penetration, and the synthesis of mass labeled lipids, including free fatty acids and phospholipids, for determination of uptake, distribution and metabolism.
Experience with organic synthesis is required. Candidates with solid background in organic synthesis and medicinal chemistry will be preferred. Experience with molecular modelling is an advantage, but not a requirement. Excellent written and oral communication skills in English is a requirement.
For further information please contact Professor Trond Ulven (e-mail: firstname.lastname@example.org).
Application, salary etc.
Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.
The successful applicant will be employed in accordance with the agreement of 10 November 2015 on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations).
The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Application must be made in the form of a Declaration of Interest including the following:
• A research proposal/description of your approach to the above project (max one page excluding references)
• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages) (please attach this under box "Application form")
• Detailed CV, including personal contact information
• Copies of diplomas, Bachelor as well as Master’s degree, including transcript of notes/grades
• At least two signed reference letters. Should your referees wish to send their letters directly to us, please have them use e-mail: email@example.com mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.
Further information about the PhD-study can be found at the homepage of the University .
Applications must be submitted electronically using the link below. Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.
Further information for international applicants about entering and working in Denmark.
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