C-terminal protein modification

Updated: about 1 month ago
Deadline: 05 Aug 2024

Discover new methods to functionalize the C-terminus of peptides and proteins

At the Department of Chemical Engineering at Delft University of Technology we are looking for a postdoctoral researcher in synthetic organic chemistry for the development of methods for the selective functionalization of the C-terminus of peptides and proteins. The project will focus on the development of new methods as well as optimization of a recently discovered method, both with the aim of application in single molecule protein sequencing. Methods likely involve photocatalysis and click chemistry, and need to be analyzed for substrate scope and yield. The project will be carried out in a close collaboration with an industrial partner actively working in this field towards practical implementation of the related technologies. Despite having an applied focus, the project is fundamental in nature.

The expected starting date is as soon as possible. The position is for 2 years.

As a postdoctoral researcher you will

*Carry out synthesis of reagents and testing these reagents in C-term modification of peptides

*Characterize products with an array of physical chemical methods (NMR, MS, HPLC, etc)

*Develop, analyze and optimize new synthetic methods

*Apply methods developed on peptides to full scale proteins

*Provide daily guidance to BSc and/or MSc students working with you on this project

*Keep up to date with the literature related to the research project

*Actively participate in the scientific discussion within the group

We are looking for an ambitious candidate with a PhD in organic chemistry (or have submitted a PhD thesis prior to taking up the appointment) or relevant experience. Substantial experience in synthetic organic chemistry and affinity with biomolecular chemistry and (photo)catalysis are required.

Our perfect candidate has:

*A PhD in organic chemistry/ molecular catalysis / chemical biology / peptide chemistry / medicinal chemistry

*Experience with synthesis and characterization of organic compounds

*Experience with synthesis and characterization of peptides and other biomolecules

*Experience with reaction optimization

*Affinity with photocatalysis and click chemistry

*Proven skills of (relatively) independent scientific writing in English

Good communication skills in English

*Ability to collaborate and adapt to an international and multidisciplinary research team.

Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. The TU Delft offers a customisable compensation package, discounts on health insurance, and a monthly work costs contribution. Flexible work schedules can be arranged.

For international applicants, TU Delft has the Coming to Delft Service . This service provides information for new international employees to help you prepare the relocation and to settle in the Netherlands. The Coming to Delft Service offers a Dual Career Programme for partners and they organise events to expand your (social) network.

Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

With more than 1,000 employees, including 135 pioneering principal investigators, as well as a population of about 3,400 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we train students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers and science communicators.

Click here to go to the website of the Faculty of Applied Sciences.

The Advanced Soft Matter (ASM) research group is focused on the development and characterisation of new, functional, soft molecular and polymer materials, as well as the design and synthesis of new functional molecules and polymers. Examples include dynamic gels and surfactants, self-healing materials and out-of -equilibrium systems, often formed by self-assembly or directed self-assembly of molecular building blocks. Materials of interest may range from bio-organic to opto-electronic, nanostructured materials.

For more information about this vacancy, please contact the PI, Dr. Rienk Eelkema, Department of Chemical Engineering, [email protected]     

Applications should include:

(1) Curriculum Vitae (with publication list)

(2) A letter of application in which you explain both your motivation and the relevance of your skills and experience for this research project.

(3) Names and contact details of 2 referees.

The application letter should be on topic; generic letters will cause your application to be rejected immediately. DO NOT submit general recommendation letters with your application, these will not be considered. For further information about the application procedure, please contact Ms. Veby Agus, [email protected]

The applications will be reviewed as soon as they are received, therefore you are invited to submit your application as soon as it is ready. We reserve the right to stop the selection procedure before the deadline once a suitable candidate has been identified.

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