In osteosarcoma, low expression or frequent mutations of single components of the DAXX/ATRX histone H3.3 chaperon/nucleosome remodeling complex lead to increased levels of RNA:DNA hybrid related genomic stability at telomere and non-telomere sites. The project aims to understand mechanisms that recruit ATRX/DAXX to sites of RNA:DNA hybrids. In a second step, therapeutic strategies that block ATRX/DAXX recruitment to RNA:DNA hybrid sites such as telomeres will be investigated. Candidates should have experience in standard methodology related to protein-protein interaction, cancer cell biology, immunofluorescence microscopy and cell culture techniques. Specialized experience in the analysis of genomic stability and chromatin structure, analysis of DNA replication, RNA biology and experience in FISH technology are an additional plus during the candidate selection process.
Similar Positions
-
Scientific Research Technician Cancer Stem Cells (Veterinary Faculty), AcademicTransfer, Netherlands, about 7 hours ago
We are looking for a scientific research technician who will be providing technical support to our research team. You will be working closely with 2 PhD candidates and with Master's students. You ...
-
Technician In Vascular Cell Biology/Immunology, Leiden University, Netherlands, 7 days ago
Apply now The Faculty of Science and the Institute for Biology Leiden are looking for an: Technician in vascular cell biology/immunology Key responsibilities The analyst will work in close collabo...
-
Research Technician, Case Lab, New England HERC, United States, 15 days ago
Details Posted: 12-Apr-24 Location: Cambridge, Massachusetts Type: Full-time Salary: Open Categories: Research - Laboratory/Non-Laboratory Staff/Administrative Internal Number: 23925 Job Descripti...
-
Bioinformaticians Biodiversity Cell Atlas Database, Centre for Genomic Regulation, Spain, about 19 hours ago
The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. T...
-
Laboratory Assistant Microbial Fermentation And Purification, Vrije Universiteit Brussel, Belgium, 1 day ago
MITH is an academic research group developing diagnostic and therapeutic biopharmaceuticals with a strong vision to bring innovation from the bench to bedside. We have established a cleanroom faci...
-
Scientist (M/F/D) “Regulatory Affairs Cell Line Banking And Customer Support”, Leibniz, Germany, 1 day ago
Scientist (m/f/d) “Regulatory Affairs Cell Line Banking and Customer Support” at the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany, in th...