Postdoc - Soskic Lab Genomics Research Centre (Grant Open Targets)

HT is a new interdisciplinary research institute, created and supported by the Italian government, whose aim is to develop innovative strategies to promote human health and aging through a multidisciplinary and integrated approach, combining genomics, computational and structural biology and neuroscience, as well as data and decisions sciences.

The Soskic group at HT is looking for a candidate with expertise in cellular immunology. Soskic group uses a wide range of immunological and genomic assays to study B cell biology, antibody diversity and variation in the human immune system in health and disease https://humantechnopole.it/en/research-groups/soskic-group/ .

We are seeking for an enthusiastic and motivated postdoc with strong immunology background to join our interdisciplinary team on an ambitious project that will use cutting-edge techniques to study how genes associated with immune diseases modulate B cell functions. 

This project is funded by Open Targets (https://www.opentargets.org/ ), grant number OTAR3086, which represents a collaboration between academic and industrial partners aiming to identify new drug targets. The project will be in close collaboration with Dr. Gosia Trynka at Wellcome Sanger Institute, Cambridge UK. As a part of the project, the candidate will have a short stay at Trynka lab at Wellcome Sanger Institute (1-3 months).

The successful candidate will report to Blagoje Soskic.

Key Tasks and Responsibilities:

• Leverage the recent advances in CRISPR to link genes important for immune diseases to B cell functions;
• Reveal the underlying molecular mechanisms of autoimmune disease susceptibility and define new routes for therapeutic intervention;
• Managing experimental and analytical workflows within their project;
• Generating reliable data for publication in the projects to which they are assigned and recording all data and results in specified forms (paper and electronic);
• Publishing reproducible research;
• Interacting and supporting other group members whenever needed;
• Sharing and discussing research results with partners and collaborators.