Development of saccharide analogues for protein functionalization and as ligands for binding studies with carbohydrate binding molecules (CBMs). Multivalent presentation of CBMs.

25 Feb 2024
Job Information

Organisation/Company

Università degli Studi di Firenze

Department

Chemistry Department "Ugo Schiff" - DICUS

Research Field

Chemistry » Organic chemistry

Researcher Profile

First Stage Researcher (R1)

Country

Italy

Application Deadline

15 Apr 2024 - 23:59 (Europe/Brussels)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

40

Offer Starting Date

1 Nov 2024

Is the job funded through the EU Research Framework Programme?

HE / MSCA

Marie Curie Grant Agreement Number

101119492

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

In the framework of the MSCA-Doctoral Network "European Network on the Supramolecular Chemistry of Carbohydrates", DC4 will be in charge of the project “Development of saccharide analogues for protein functionalization and as ligands for binding studies with carbohydrate binding molecules (CBMs). Multivalent presentation of CBMs.”

The project, in collaboration with Prof. Cristina Nativi, aims to synthesise glycosidic analogues of biologically relevant carbohydrates for their conjugation with proteins and materials for molecular recognition studies with synthetic receptors. The group has extensive experience in carbohydrate chemistry for the development of glycomimetics and saccharide analogues for the tuning of glycan-protein recognition events. This project also aims to conjugate synthetic receptors to obtain functional materials to study the role of multivalent presentation in carbohydrate recognition and separation.

Background literature:

Niosomes Functionalized with a Synthetic Carbohydrate Binding Agent for Mannose-Targeted Doxorubicin Delivery. Pharmaceutics, 2023, 15 (1), art. no. 235.

Towards Biomimetic Recognition of Glycans by Synthetic Receptors. ChemPlusChem 2023, e202300598

Biomimetic Tweezers for N-Glycans: Selective Recognition of the Core GlcNAc2 Disaccharide of the Sialylglycopeptide SGP Chem. Eur. J., 2023, 29 (18), art. no. e202203591.

Requirements

Research Field

Chemistry » Organic chemistry

Education Level

Master Degree or equivalent

Skills/Qualifications

Experience in organic chemical research is strongly recommended.

Languages

ENGLISH

Level

Excellent

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Department of Chemistry “Ugo Schiff” DICUS, University of Florence

Country

Italy

State/Province

Toscana

City

Sesto Fiorentino, Firenze

Postal Code

50019

Street

Via della Lastruccia, 13

Geofield

Where to apply

Website

http://www.enscc.eu

Contact

State/Province

FI

City

Sesto Fiorentino, Firenze

Website

https://www.chim.unifi.it/

Street

via della Lastruccia 13

Postal Code

50019

E-Mail

[email protected]

STATUS: EXPIRED