Covalent podands and macrocycles for the molecular recognition of carbohydrates

25 Feb 2024
Job Information

Organisation/Company

Università degli Studi di Firenze

Department

Chemistry Department "Ugo Schiff" - DICUS

Research Field

Chemistry » Organic chemistry

Researcher Profile

First Stage Researcher (R1)

Country

Italy

Application Deadline

15 Apr 2024 - 23:59 (Europe/Brussels)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

40

Offer Starting Date

1 Nov 2024

Is the job funded through the EU Research Framework Programme?

HE / MSCA

Marie Curie Grant Agreement Number

101119492

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

In the framework of the MSCA-Doctoral Network "European Network on the Supramolecular Chemistry of Carbohydrates", DC3 will be in charge of the project “Covalent podands and macrocycles for the molecular recognition of carbohydrates”.

The project aims to develop amino- and imino-based podand and macrocycle receptors for the biomimetic (non-covalent) recognition of biologically relevant carbohydrates. Recent advances in our group have led to synthetic receptors that target glycans and are biologically active in several contexts, from antiviral compounds against enveloped health risk viruses to apoptotic agents against cancer cell lines. The experimental work will be largely represented by the synthesis and characterisation of new synthetic receptors. The project will also include the molecular design of new receptors and the determination of their binding properties using spectroscopic and calorimetric techniques with particular reference to NMR and ITC.

Background literature:

Towards Biomimetic Recognition of Glycans by Synthetic Receptors. ChemPlusChem 2023, e202300598

A Simple Biomimetic Receptor Selectively Recognizing the GlcNAc2 Disaccharide in Water. Angew. Chem. Int. Ed. 2021, 60, 11168 – 11172.

A biomimetic synthetic receptor selectively recognizing fucose in water. Chem. Eur. J. 2018, 24, 6828-6836.

Requirements

Research Field

Chemistry » Organic chemistry

Education Level

Master Degree or equivalent

Skills/Qualifications

Experience in organic chemical research is strongly recommended.

Languages

ENGLISH

Level

Excellent

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Department of Chemistry “Ugo Schiff” DICUS, University of Florence

Country

Italy

City

Sesto Fiorentino, Firenze

Postal Code

50019

Street

Via della Lastruccia, 13

Geofield

Where to apply

Website

http://www.enscc.eu

Contact

City

Sesto Fiorentino, Firenze

Website

https://www.chim.unifi.it/

Street

via della Lastruccia 13

Postal Code

50019

E-Mail

[email protected]

STATUS: EXPIRED