15 Jan 2024
Job Information
- Organisation/Company
Hebrew University of Jerusalem- Department
Biochemistry and Molecular Biology I- Research Field
Biological sciences » Biology- Researcher Profile
First Stage Researcher (R1)- Country
Israel- Application Deadline
1 Mar 2024 - 09:00 (Asia/Jerusalem)- Type of Contract
Temporary- Job Status
Full-time- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Iron is vital for all animals, including humans. However, its dual nature presents a paradox: while essential, iron can also catalyze the production of oxygen-free radicals, leading to oxidative injury, disease conditions, and death, death. This duality underscores the critical need for precise regulation of iron levels in response to changes in oxygen levels and its metabolic products, i.e., reactive oxygen species (ROS). Unraveling the mechanisms behind this meticulous control at cellular and whole-animal levels represents an unresolved challenge in biology and medicine.
Our laboratory has made some fundamental discoveries in this area. We've uncovered that the ferritin complex FTN-1's expression significantly intensifies under low oxygen conditions (hypoxia) and conversely diminishes in standard oxygen environments (21%). This regulation, intriguingly, is significantly influenced by the transcription factor HIF-1 in a unique and complex manner. Additionally, our research suggests that neuronal control plays a pivotal role in the expression of FTN-1. However, the underlying mechanisms of action are still unknown.
Understanding these processes is crucial, as ferritin plays a central role in iron regulation across all animals, from simple bacteria to humans. This is where your involvement becomes vital. We are seeking dedicated PhD research students and postdocs to explore this fascinating field. You will use various advanced methodologies, including microscopy, genetics, and biochemical techniques, and work with both C. elegans and human cell lines as model systems.
If you're interested and eager to learn more, please send your resume to Prof. Einav Gross at [email protected] and become part of a team at the forefront of biological and medical sciences.
We offer full scholarships to suitable PhD and postdoc candidates. While experience in C. elegans and tissue culture is beneficial, it is not required. However, experience in basic molecular biology (cloning, PCR) is essential.
Candidates will be considered on a rolling basis until the positions are filled.
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
- Languages
- ENGLISH
- Level
- Good
Additional Information
Work Location(s)
- Number of offers available
- 2
- Company/Institute
- Hebrew University of Jerusalem
- Country
- Israel
- State/Province
- Please select:
- City
- Jerusalem
- Postal Code
- 9112102
- Street
- Ein Kerem, 9112102, Jerusalem
Where to apply
[email protected]
Contact
- State/Province
Please select:- City
Jerusalem- Website
https://medicine.ekmd.huji.ac.il/en/publications/researchersPages/pages/einavg.aspx- Street
Ein Kerem, 9112102, Jerusalem- Postal Code
9112102
[email protected]- Phone
026758338
STATUS: EXPIRED
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