Post-doctoral Fellow in the School of Biological Sciences

15 May 2024
Job Information

Organisation/Company

THE UNIVERSITY OF HONG KONG

Research Field

Biological sciences

Researcher Profile

Recognised Researcher (R2)
Established Researcher (R3)

Country

Hong Kong

Application Deadline

1 Jul 2024 - 00:00 (UTC)

Type of Contract

Other

Job Status

Full-time

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Work type: Full-time
Department: School of Biological Sciences (26000)
Categories: Senior Research Staff & Post-doctoral Fellow

Applications are invited for appointment as Post-doctoral Fellow in the School of Biological Sciences (Ref.: 526683), to commence as soon as possible for 2 years, with the possibility of renewal.

Applicants should have a PhD in structural biology, biochemistry, or a related field. He/She will have a proven track record in using cryo-EM for protein structure determination. Experience in (membrane) protein expression/purification and cryo-EM sample preparation/data collection and proficiency in using common structural biology software are required. A good understanding of ion channel structure and function will be an advantage. A commitment to scientific excellence, interest in interdisciplinarity, and good collaboration skills are expected.

Our group uses state-of-the-art structural and biophysical approaches to unravel the molecular principles underlying the function of membrane proteins mediating ion and lipid transport. Work from our group has revealed electrostatic and hydrophobic gating (eLife 2018, Nat. commun. 2021a) and the associated kinetic mechanism (Nat. commun. 2021b) in an unconventional ligand-gated chloride channel. Using cryo-electron microscopy (cryo-EM), our work has further provided the structural basis for drug binding (Nat. commun. 2022) and ligand efficacy (EMBO J 2023) in this channel, both of which will be crucial to the development of novel therapeutic strategies.

The project is aimed at understanding the mechanisms of membrane transport proteins using cryo-EM and complementary methods. We have access to the latest Krios and Glacios microscopes at the Faculty of Medicine as well as computational resources for cryo-EM data processing. Our lab has the necessary equipment for a host of molecular biology, large-scale mammalian cell culture, and protein biochemistry experiments and is equipped with an integrated electrophysiology system for functional investigations. For more details about this position, please contact Dr. A.K.M. Lam ([email protected] ).

A competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits.

The University only accepts online applications for the above post. Applicants should apply online and upload an up-to-date C.V., including a brief description of your most significant research achievements and contact information of at least two references, and a cover letter in PDF format. Review of applications will commence as soon as possible and continue until July 1, 2024,  or until the post is filled, whichever is earlier.

Requirements
Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

THE UNIVERSITY OF HONG KONG

Country

Hong Kong

City

Pok Fu Lam, Hong Kong

Geofield

Where to apply

Website

https://www.timeshighereducation.com/unijobs/listing/372954/-post-doctoral-fell…

Contact

City

Pok Fu Lam, Hong Kong

STATUS: EXPIRED