8 Mar 2024
Job Information
- Organisation/Company
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt- Research Field
Medical sciences- Researcher Profile
Recognised Researcher (R2)
Established Researcher (R3)- Country
Germany- Application Deadline
28 May 2024 - 15:30 (UTC)- Type of Contract
To be defined- Job Status
Other- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Area of research:
Scientific / postdoctoral posts
Job description:Postdoc - Department Signaling and Translation (f/m/x)
102333
Full time
Neuherberg near Munich
We are Helmholtz Munich. In a rapidly changing world, we discover breakthrough solutions for better health.
Our research is focused within the areas of metabolic health/diabetes, environmental health, molecular targets and therapies, cell programming and repair, bioengineering, and computational health. We particularly excel in the fields of basic research, bioengineering, artificial intelligence, and technological development.
Through this research, we build the foundations for medical innovation. Together with our partners, we seek to accelerate the transfer of our research, so that laboratory ideas can reach society and improve people’s quality of life at the fastest rate possible.
This is what drives us. Why not join us and make a difference?
The Research Unit (RU) Signaling and Translation (SAT) investigates how key cellular signaling pathways control health and disease. Our aim is to understand how physiological signaling maintains homeostasis and triggers efficient responses to environmental changes or immune challenges. At the same time, we elucidate how defective or aberrant signaling pathways are contributing to autoimmunity, inflammation, or cell death, which can trigger human pathologies such as diabetes and cancer. We fill the gap between basic science and clinical innovations by providing direct access to technologies and expertise that will foster translation of new discoveries into pioneering targeting strategies. Thus, in SAT we develop new therapeutic concepts to improve treatment of common and unmet medical needs.
Treatment of rheumatoid arthritis (RA) relies on interfering with immune cell signaling. The successful candidate will contribute to this project which is targeting TRAF6-UBC13-mediated signaling to develop RA therapeutics. First-in-class TRAF6-UBC13 inhibitors have been developed that improve disease outcome in a preclinical RA mouse model. In this m4-Award-funded project, the current lead molecules will be optimized to nominate preclinical candidates.
Prof. Matthias Tschöp (Dr. Med., Dr. hc.), CEO of Helmholtz Munich: "We believe that excellent research requires a range of different perspectives. Diverse teams reach better solutions and are more innovative in their research topics.
Establishing our Diversity Management Strategy demonstrates our commitment to ensuring an appreciative company culture based on mutual respect. We are also implementing diversity-sensitive processes throughout our whole organization."
Your tasks
- Biochemical and biophysical validation of novel TRAF6-Ubc13 inhibitors (AlphaScreen assays, in vitro ubiquitination assays, and microscale thermophoresis)
- Cellular validation of novel TRAF6-Ubc13 inhibitors (co-IP assays, cellular ubiquitination assays, testing of the small molecule inhibitors on TCR signaling in PBMCs)
- Coordination of outsourcing activities with CROs
Your profile
- Doctoral degree in natural sciences (biochemistry, biology, or a related discipline)
- Profound expertise in working with E3 ligases and the ubiquitination machinery in general
- Very good knowledge in performing biochemical and cell-based ubiquitination assays
- Good protein expression and purification skills
- Expertise in working with cell lines and primary cell culture
- Strong motivation, scientific curiosity, and commitment to scientific excellence
- Excellent writing and communication skills
- Team player and enthusiasm to work in a collaborative environment
Benefits
Since 2005, we hold the TOTAL E-QUALITY award for exemplary action in the sense of an equal-opportunity organizational culture.
Helmholtz Munich is actively committed to diversity and inclusion in practice and is sustainably committed to equality.
The Diversity Charter has set itself the goal of promoting diversity in the world of work. By signing the charter, we commit ourselves to create an appreciative working environment for all employees.
If you fulfil all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public-Sector Employees (TVöD). This position is for a fixed term of 2 years.
We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.
Interested in applying?
If you have any questions, feel free to contact Dr. Kamyar Hadian, 089 3187-2664, who will be happy to help.
Your application should include
We are Helmholtz Munich.
Why join us?
Read more
Helmholtz Munich
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Department Signaling and Translation
Ingolstädter Landstr. 1
85764 Oberschleißheim / Neuherberg bei München
This research center is part of the Helmholtz Association of German Research Centers. With more than 42,000 employees and an annual budget of over € 5 billion, the Helmholtz Association is Germany's largest scientific organisation.
Requirements
Additional Information
- Website for additional job details
https://jobs.helmholtz-muenchen.de/jobposting/9f9e544c331dae914c32883809c513acd…
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
- Country
- Germany
- City
- Neuherberg (bei München)
- Geofield
Where to apply
- Website
https://jobs.helmholtz-muenchen.de/jobposting/9f9e544c331dae914c32883809c513acd…
Contact
- City
Neuherberg- Website
https://www.helmholtz-muenchen.de/en- Street
Ingolstädter Landstraße 1- Postal Code
85764
[email protected]- Phone
+49 89 3187-0- Fax
+49 89 3187-3322
STATUS: EXPIRED