Postdoc Arboviruses/Biotechnology

14 May 2024
Job Information

Organisation/Company

Otto von Guericke Universität

Research Field

Biological sciences

Researcher Profile

Recognised Researcher (R2)

Country

Germany

Application Deadline

31 May 2024 - 23:00 (UTC)

Type of Contract

To be defined

Job Status

Full-time

Hours Per Week

To be defined

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Lab:
Our lab focuses on RNA viruses and their constraints of viral evolution on a molecular level. Put as a simple question: Why do viruses evolve the way they do and not in other ways? For this, we look at single mutations, secondary RNA structures, genome organisation, enzymatic functions and cellular pathways. To help us address this question, we use a diverse set of methods, such as reverse genetics systems,  Next Generation Sequencing (NGS), proteomics or classical virological methods. We are also interested in developing new methods that will allow us new lines of investigation. We aim to understand the individual evolutionary paths viruses take in different situations and what might be limiting factors in this process. Can we use this knowledge and processes for the development of new therapeutic strategies?

Project: 

The project will develop a new set of methods for the lab. It will initially focus on the establishment of fluorescent reporter cell lines, in mosquito cells for the detection of arbovirus infection. The project will use proteomics to identify suitable cellular proteins in different mosquito cell lines. Cellular candidates interacting with arbovirus proteases will be characterised further and serve as starting point for a fluorescent reporter construct. The reporter construct will be optimised for the expression and activation by arboviruses in mosquito cells. Finally, the reporter construct will be tested and benchmarked in various assays, including a proof-of-concept small molecule screen.

You…
PhD or equivalent in Molecular Virology (or related subject)
Extensive experience with Arboviruses and insect cell culture
Extensive experience with molecular biology/cloning methods
Experience with proteomics beneficial
Experience with fluorescence microscopy and FACS beneficial
Self-motivated, organised and willing to supervise students in the lab
Fluent in English (written and oral) mandatory

What we offer…

Postdoc Position (m/f/d) (TV-L 13) for up to 18 months
New, highly motivated research group using molecular biology to gain
insights into RNA viruses, virus-host interactions and viral evolution
Possibility to attend (international) conferences
Possibility for (international) collaborations
Well-equipped facilities
Safe & supportive work environment

Application:

Apply with a motivation letter (why specifically this lab and project)
CV and contact details of 2 referees
Address application to Björn Meyer, PhD (also get in touch for informal inquiries)
Send to: [email protected]
Applications are open until the position is filled, start date: as soon as possible

Requirements
Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Otto von Guericke Universität

Country

Germany

Geofield

Where to apply

Website

https://jobrxiv.org/job/otto-von-guericke-universitat-27778-postdoc-arboviruses…

Contact

Website

http://www.immb.ovgu.de/Forschung/AG+Meyer.html

STATUS: EXPIRED