Tissuloid model for studying tissue self-organization

21 Mar 2024
Job Information

Organisation/Company

CEA - groupe

Research Field

Biological sciences » Biology
Technology » Materials technology
Physics

Researcher Profile

Recognised Researcher (R2)
Leading Researcher (R4)
First Stage Researcher (R1)
Established Researcher (R3)

Country

France

Application Deadline

29 Apr 2024 - 22:00 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

15 Oct 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Project summary:

Tissue formation is a highly regulated morphogenetic process, involving iterative interactions among cells and cell groups, guiding cellular differentiation and patterning on a large scale. This complex, yet not well-understood, emergent phenomenon enables individual cells to self-organize into intricate macroscopic structures. The dysfunction of tissue morphogenesis is implicated in various pathologies, including cancer.

In our team, we are developing an original approach to create a pattern of macroscopic tissue-like structures, which we have named tissuloids, from single cell populations. This technology offers a unique opportunity to explore self-organization processes at every scale, from the micro (cell) to the macro (tissue) level.

As we embark on this new project to investigate the mechanisms of tissue morphogenesis and pathology, we are seeking a motivated PhD candidate to join us in unravelling the mysteries of tissue self-organization. In this role, you will tackle fundamental questions such as: How do the mechanical properties of the microenvironment influence cellular behaviour? How do changes at the cellular level manifest in tissue patterning? What role do emergent phenomena play in this complex process?

 

Student role: As part of our team, you will characterize the mechanical properties of extracellular matrices and cells, investigate the forces exerted by cells and cell assemblies, analyze the dynamics of tissuloid assembly, and decipher the mechanical and biochemical signals involved. You will utilize the newest technologies in 3D cell culture, mechanobiology, and imaging to make an impact in the fields of tissue engineering and translational research.

Funding category: Contrat doctoral
GRAL fellowship for funding as a Laboratoire d’excellence (Labex) through the “Investissements d’avenir”
PHD Country: France

Requirements
Specific Requirements

Preferred skills: We are seeking a motivated candidate with an M.Sc. in biology (or biophysics), (bio)material engineering, (bio)mechanical engineering, or soft matter physics, who is eager to explore new fields. Background knowledge in cell biology is required, and experience in cell culture, cell imaging, and image analysis would be appreciated.

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

CEA - groupe

Country

France

City

Grenoble

Geofield

Where to apply

Website

https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/121492

STATUS: EXPIRED