22 Mar 2024
Job Information
- Organisation/Company
CNRS- Department
Ecologie & Biologie des Interactions- Research Field
Chemistry » Biochemistry
Physics » Biophysics
Biological sciences » Biological engineering- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
11 Apr 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
2 Sep 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Molecular interactions of Mycobacterium bovis and Mycobacterium avium ssp. paratuberculosis with environmental amoebae.
Environmental free-living amoebae (FLA) have been hypothesized as reservoir components and vectors of Mycobacterium bovis (Mbo) and/or M. avium ssp. paratuberculosis (Map) and/or other mycobacteria that interfere with the diagnosis of tuberculosis. They could have an important role in the persistence of bovine tuberculosis and paratuberculosis respectively. Indeed, it has been experimentally shown that some mycobacteria may persist or multiply within FLA in vitro, but very few studies have addressed the role of environmental FLA in allowing survival and shaping virulence of mycobacteria
The objectives of the project are 1) to study the permissiveness of environmental FLA isolates to Mbo and Map infection in vitro and within mesocosms and 2) to decipher gene expression of Map and Mbo, at the transcriptomic and proteomic level during infection.
The position is part of the AMITUB project, supported by the ANR agency. It will be conducted under the supervision of Yann Héchard and Ascel Samba within the EBI laboratory (UMR CNRS 7267) at the University of Poitiers, in collaboration with the ISP laboratory (INRAE Nouzilly), the LDAR24 laboratory (Coulounieix-Chamiers) and the LNR laboratory (ANSES, Maisons-Alfort). Our labs have a long-term experience in amoeba and Mycobacterium studies.
Requirements
- Research Field
- Chemistry
- Education Level
- PhD or equivalent
- Research Field
- Physics
- Education Level
- PhD or equivalent
- Research Field
- Biological sciences
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Chemistry » Biochemistry
- Years of Research Experience
- None
- Research Field
- Physics » Biophysics
- Years of Research Experience
- None
- Research Field
- Biological sciences » Biological engineering
- Years of Research Experience
- None
Additional Information
Eligibility criteria
The candidate should have a strong experience in host-pathogen interactions, especially via in transcriptomics and/or proteomics approaches. Skills in writing in English are expected.
- Website for additional job details
https://emploi.cnrs.fr/Offres/CDD/UMR7267-YANHEC-003/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Ecologie & Biologie des Interactions
- Country
- France
- City
- POITIERS
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR7267-YANHEC-003/Candidater.aspx
Contact
- City
POITIERS- Website
http://ebi.labo.univ-poitiers.fr/
STATUS: EXPIRED