Updated: 2 months ago
Location: Tours, CENTRE
Job Type: FullTime
Deadline: 31 Mar 2024
23 Feb 2024
Job Information
- Organisation/Company
INSERM DR Grand Ouest- Research Field
Neurosciences
Pharmacological sciences- Researcher Profile
Recognised Researcher (R2)- Country
France- Application Deadline
31 Mar 2024 - 23:59 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
38.5- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
| The INSERM U1253 laboratory is recruiting a research associate (with 0 to 3 years post-doc experience) to conduct a research project funded by the ANR (French Research National Agency) aiming at developing PET tracers for α-synuclein. The protein α-synuclein accumulates and aggregates in the brain of Parkinson disease patients, causing the death of dopaminergic neurons in the striatonigral pathways. Being able to monitor the α-synuclein load in PD patients would enable a finer diagnostic and stratification of patients to i) better understand disease progression and the relation between α-synuclein load and symptoms and ii) monitor the efficacy of new therapies. However, so far there is no PET radiotracer with a high specificity for α-synuclein, and binding to other aggregates such as β-amyloid is common. The aim of this project is to screen new molecules in vitro to establish their pharmacological properties using binding experiments on both cell culture preparations and brain sections and once a suitable candidate will have been identified, proceed with its in vivo characterisation and validation by preclinical PET-CT in animal models. The ideal candidate would have knowledge in pharmacology, neuroscience and neurodegenerative diseases (ideally Parkinson Disease) and previous experience (PhD or post-doc) of i) cell culture, ii) in vitro binding experiments and iii) in vivo imaging (preferentially, but not compulsory, PET and tracer development). Depending on the profile of the candidate, the lab will support competitive candidates to apply to French Fellowship opportunities. |
MAIN ACTIVITIES
• Cell cultures. • Interpretation and preparation of the data for publication, preparation of manuscript. |
ASSOCIATED ACTVITIES
| • Animal handling. • Preparation of animals for PET scans. • In vitro experiments: immunohistochemistry, histology, Western blot. |
Requirements
- Research Field
- Biological sciences
- Education Level
- PhD or equivalent
Skills/Qualifications
| • Excellent understanding of pharmacology • Previous experience in performing binding experiments. |
Specific Requirements
| • Experience in neuroimaging (preferably PET, but other modalities accepted) • Holding an animal experimentation license and previous experience in animal experimentation would be a plus. |
- Languages
- ENGLISH
- Level
- Good
Additional Information
Selection process
Applicants must send a CV and a cover letter to: Dr Hervé Boutin ([email protected] ) or Dr Sylvie Chalon
([email protected] )
Contact for further information (name, telephone/mail): Dr Hervé Boutin ([email protected] ) or Dr Sylvie
Chalon ([email protected] )
Additional comments
| Hosting Unit | |
| Code | U1253 |
| Name | iBrain |
| Director | Dr Catherine BELZUNG |
| Composition | Equipe 4: Molecular and morpho-functional imaging |
- Website for additional job details
https://ibrain.univ-tours.fr/
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Inserm - U1253 iBrain
- Country
- France
- City
- TOURS
- Postal Code
- 37000
- Street
- 10 Bd Tonnellé
- Geofield
Where to apply
[email protected]
Contact
- City
NANTES- Website
https://grand-ouest.inserm.fr/- Street
24 Boulevard Vincent Gâche- Postal Code
44200
STATUS: EXPIRED