Post-doctoral fellow Position

10 May 2024
Job Information

Organisation/Company

Center of research in myology

Department

Faculté de santé

Research Field

Biological sciences » Biology
Medical sciences » Health sciences

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

30 Jun 2024 - 00:00 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

A two-year postdoctoral position is available in the laboratory of the Pr. Benveniste and Pr. Allenbach in the Center of Research in Myology (U974 Sorbonne Université-INSERM).

The project is fully funded by the ARC foundation and will be done in collaboration with the Immunology-Immunopathology-Immunotherapy (I3) lab (U959 Sorbonne Université-INSERM-APHP).

The Pr. Yves Allenbach will coordinate the projet.

Location

The Center of Research in Myology (CRM) and i3 laboratories are interested in muscle and systemic immune responses in auto-immune conditions. They developed approaches to identify pathological mechanisms, new biomarkers for diagnosis, and innovative targeted approaches.

Our team, headed by O. Benveniste and Y. Allenbach in CRM, is a world leader in cardiac and skeletal muscle toxicity of anti-tumor immunotherapy. It is a transversal research team, pioneer in the description and the management of ICI-induced myotoxicity (Allenbach Y et al. Nature Rev Immunol 2019; Salem JE et al. NEJM 2020). Our team have established one of the world's largest biobanks of patient tissues with myotoxicity.

I3 is lab expert in immunology with a unique expertise in identifying antigen-specific T cells through the analysis of T cell receptor repertoire using deep sequencing (Barennes P et al., Nature Biotechnology, 2020).

Both laboratories offer a unique interdisciplinary environment, with biologists, immunologists, clinicians, and bioinformaticians. The candidate will be based in the the Pitié‐Salpêtrière hospital campus in Paris which offers a dynamic environment with state-of-the-art facilities and platforms.

 

Project summary and position assignment

ICI-myotoxicity, combining skeletal and or cardiac inflammation, is a rare (0.5%) and unpredictable immune-related adverse events (irAE) but the most severe (up to 60% of fatality). Thus, it is crucial to identify predictive biomarkers and clarify the pathomechanisms. For this, our team and i3 lab have obtained jointly a considerable grant from the ARC Foundation for cancer research.

The project aims at :

• identifying specific pathways in cardiac and skeletal muscle tissue for rationale therapeutic targeting
• identifying predictive T cell clonotypes associated with ICI-myotoxicity

The successful candidate will play a pivotal role in a project focused on understanding the physiopathological mechanisms of immune-mediated muscular and cardiac complications of anti-cancer immunotherapy (Immune Checkpoint Inhibitors).

They will contribute to wet and dry lab-based research, including sample management, cell sorting, single cell, single nuclei, AIRRseq, RNASeq, as well as using available workflows developed by the host laboratory (PBMC and tissue 10X Genomics®) and implementing new strategies (Xenium, 10X Genomics®).

 

 

Requirements

Research Field

Biological sciences » Biology

Education Level

PhD or equivalent

Research Field

Medical sciences » Health sciences

Education Level

PhD or equivalent

Skills/Qualifications

• PhD in immunology or solid background in immunology
• Skills in cell sorting, single cell and/or single nuclei, AIIRseq, RNASeq
• Skills in bioinformatics

Candidate will provide input into decisions on experimental approaches and techniques, keep up to date with current developments in the field, collaborate with other members of the team, liaise with external collaborators and take a lead in the presentation of results and paper writing. Good knowledge of the English language is essential.

Languages

ENGLISH

Level

Good

Research Field

Biological sciences » BiologyMedical sciences » Health sciences

Years of Research Experience

1 - 4

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Centre de recherche en myologie U974

Country

France

State/Province

Ile de France

City

Paris

Postal Code

75013

Street

105 boulevard de l'hôpital

Geofield

Where to apply

E-mail

[email protected]

Contact

State/Province

Ile de france

City

Paris

Website

https://sante.sorbonne-universite.fr/structures-de-recherche/centre-de-recherche-en-myologie
https://recherche-myologie.fr/

Street

105 boulevard de l'hopital

Postal Code

75013

E-Mail

[email protected]
[email protected]

Phone

+33140779684

STATUS: EXPIRED