9 Jan 2024
Job Information
- Organisation/Company
INSERM- Department
U1256 - NGERE- Research Field
Biological sciences- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
22 Jan 2024 - 23:59 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
37- Offer Starting Date
28 Feb 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The person will be recruited within the NGERE laboratory (Nutrition Genetic and Exposure to
Environmental Risks (https://ngere.univ-lorraine.fr ), a joint research unit of the University of
Lorraine and Inserm (U1256) whose research theme concerns study of interactions between
genetics, epigenomics and metabolic and/or nutritional factors on normal or pathological
aging.
The overall objective of this project is to develop an innovative therapeutic treatment for
patients with a genetic disease of vitamin B12 metabolism. These patients generally present
with numerous hematological and neurological symptoms for which conventional treatment
does not prevent fatal outcome or serious neurological consequences. Innovative therapeutic
strategies are therefore necessary, and our preliminary results obtained in vitro and in vivo on
transgenic animal models demonstrate that the inhibition of different forms of cellular stress
based on the pharmacological activation of the SIRT1 enzyme could constitute a new
therapeutic approach (Ghemrawi et al, Metabolism, 2019). The Post Doc recruited by FHU
ARRIMAGE (https://arrimage.univ-lorraine.fr ) will perform a preclinical study to evaluate in
vivo the effects of selected compounds with anti-oxidant or sirtuin agonist activities and their
potential synergic effects, using our transgenic mouse models.
Requirements
- Research Field
- Biological sciences
- Education Level
- PhD or equivalent
Skills/Qualifications
PhD in biological sciences or post-doc scientists with no more than 2/3 years experience.
Specific Requirements
Scientific publications in peer-reviewed journals and presentations at scientific
conferences. Published evidence of aptitude for high quality research is essential.
A strong background or experience in cell signaling and metabolism is mandatory. A
background in the study of oxidative stress is a plus.
- Languages
- ENGLISH
- Level
- Good
- Research Field
- Biological sciences
- Years of Research Experience
- None
Internal Application form(s) needed
Offre PostDoc 2024-NGERE _0.pdf
English
(351.46 KB - PDF)
Download
Additional Information
Benefits
Position, financed by Région Lorraine and CHRU of Nancy, is open from February 2024. Salary
is available for 1 year. Salary: 2.0-2.5 k€ net/month depending on the previous experience.
Eligibility criteria
PhD in biological sciences or post-doc scientists with no more than 2/3 years experience.
Selection process
Please send to the PIs: 1) a cover letter highlighting research interests, goals and previous
scientific contributions; 2) a CV listing education, publications, meeting presentations and any
other skills of interest; 3) at least 2 reference contacts.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- INSERM U1256
- Country
- France
- City
- VANDOEUVRE-LES-NANCY
- Postal Code
- 54500
- Street
- 9 AVENUE DE LA FORET DE HAYE
- Geofield
Where to apply
[email protected]
Contact
- City
VANDOEUVRE-LES-NANCY- Website
https://ngere.univ-lorraine.fr/- Street
9 AVENUE DE LA FORET DE HAYE (CAMPUS BRABOIS SANTE BAT C 2E ETAGE)
[email protected]
STATUS: EXPIRED
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