MSCA-DN position "ACINETWORK" Monoclonal antibodies against immunogenic Acinetobacter baumannii glycoepitopes (Inserm, France)
18 Mar 2024
Job Information
- Organisation/Company
IRCM - Cancer Research Institute of Montpellier- Research Field
Biological sciences- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
11 Apr 2024 - 17:00 (Europe/Brussels)- Type of Contract
Temporary- Job Status
Full-time- Offer Starting Date
1 Sep 2024- Is the job funded through the EU Research Framework Programme?
HE / MSCA- Marie Curie Grant Agreement Number
101119795- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Successful vaccination against Acinetobacter baumannii (Ab) requires a set of innovations in the classical glycan-carrier protein immunization approach. One of the most relevant steps in this process, the design of the glycan portion of the complex, is limited by the knowledge of the exact glycoepitope. An elegant approach to determine this epitope consist of using a panel of antibodies to block the recognition between the glycan-bearing peptide and the cells of the immune system. However, raising antibodies against the glycan structure using immunisation is a challenging process as natural immunity is rather inefficient at this task. Therefore, a synthetic antibody-engineering approach, such as phage-display, bares more promise as it circumvents the need to properly activate various cellular immune components. In the DC9 Individual research project, the fellow will focus on raising monoclonal antibodies against the synthetic Ab glycoepitopes available from the consortium. For this purpose, an in-house available synthetic antibody library will be used, as well as an additional immune antibody library will be created from patients infected with Ab. Antibodies selected for their best binding and functional abilities will be further reformatted in full IgG, in order to achieve the best format for experimental studies as well as suitable nM affinities. Efficacies of the newly synthetized antibodies will be then functionally studied both in vitro as well as in vivo.
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
Specific Requirements
Eligible applicants must not have resided in the country where the research training activities will take place for more than 12 months in the 3 years immediately prior to the recruitment date (and not have carried out their main activity (work, studies, etc.) in that country).
Equal opportunities policy without distinction on the grounds of gender, racial or ethnic origin, religion or belief, disability, age or sexual orientation will be applied.
- Languages
- ENGLISH
- Level
- Good
Additional Information
Selection process
All applications shall be conveyed exclusively through the ACINETWORK website at www.acinetwork.eu starting from March 11, 2023, and no later than April 11, 2024, at h 17:00 CET. In particular, the following mandatory documents shall be included in the application by uploading them as PDF files along with the application form:
- 1) an updated CV (EU pass format: https://europa.eu/europass/it/create-europass-cv ) including the details of education/qualifications, work experience, language skills, list of publications, participation in funded research project and other relevant skills;
- 2) copy of a valid ID/Passport;
- 3) a letter giving reason for his/her motivation for the post (max 1 page, Form 1 );
- 4) two recommendation letters (prepared using the template contained in Form 2 ) must be sent directly by the referees to [email protected] ;
- 5) the certified copy of the Academic degree translated into English (usually the Master Degree) which would formally entitle him/her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited. In case the degree has not been obtained yet, it is necessary to send a declaration of the university stating that the degree will be obtained by 31/12/2024;
- 6) the Academic Transcript of Records;
- 7) letter of research statement, describing the applicant’s research experience in relation with the project/s s/he is applying for (max 1500 words, Form 3 ). The letter shall report a description of the applicant’s master research project and a self-evaluation on scientific and soft skills.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Inserm - IRCM
- Country
- France
- City
- Montpellier
- Postal Code
- 34000
- Street
- 208 rue des Apothicaires
- Geofield
Where to apply
- Website
https://acinetwork.eu/start-you-application/
Contact
- State/Province
France- City
Montpellier- Website
https://www.inserm.fr- Street
208 Av. des Apothicaires, 34090 Montpellier- Postal Code
34090
[email protected]
STATUS: EXPIRED