Deciphering the complex energy landscape of the human chaperone HSP90 at atomic resolution using advanced NMR methods

18 Mar 2024
Job Information

Organisation/Company

CEA

Department

Structural Biology Institute

Research Field

Chemistry » Physical chemistry
Physics » Biophysics
Chemistry » Biochemistry

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

1 May 2024 - 23:59 (Europe/Paris)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

39

Offer Starting Date

1 Oct 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

A PhD position is available in the NMR of Large Assembies group led by Dr. Boisbouvier, at the Structural Biology Institute (IBS) in Grenoble, France. The successful candidate will use advanced isotope labeling and NMR methods at variable temperature and pressure to identify and characterize the structure and dynamics of rare functional states of the human chaperone HSP90. The position is funded by the French Atomic Energy and Alternative Energies Commission (CEA). The successful candidate will work under the supervision of Dr. Boisbouvier (IBS, Grenoble) and in close collaboration with Dr. E. Lescop (ICSN, Gif sur Yvette).

Requirements

Research Field

Chemistry » Physical chemistry

Education Level

Master Degree or equivalent

Skills/Qualifications

Candidates should hold or prepare an Engineer diploma or a Master degree in physical chemistry, structural biology, biophysics or a related field.

Languages

ENGLISH

Level

Excellent

Research Field

Chemistry » Physical chemistry

Years of Research Experience

None

Additional Information
Benefits

Gross salary: €2,561/month, health insurance, partial reimbursement of local transport expenses, 50 days vacation a year.

Duration : 3 years.

Eligibility criteria

Candidates should hold or prepare an Engineer diploma or a Master degree in physical chemistry, structural biology, biophysics or a related field.

Selection process

Interested candidates should send a CV, a covering letter and the names and e-mail addresses of two referees. These documents should be sent by e-mail to [email protected] and [email protected] by May 1st 2024.

Additional comments

Relevant Publications of the Teams:

• Henot et al. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi:10.1038/s41467-022-35399-8
• Pozza et al. “Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure”. Nature Communications (2022). doi: 10.1038/s41467-022-29410-5
• Törner et al. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi:10.1038/s41467-022-30042-y
• Gauto et al. “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex“. Nature Communications (2019). doi:10.1038/s41467-019-10490-9
• Mas et al. “Structural Investigation of a Chaperonin in Action RevealsHow Nucleotide Binding Regulates the Functional Cycle“. Science Advances  (2018). doi: 10.1126/sciadv.aau4196.

Work Location(s)

Number of offers available

1

Company/Institute

CEA/Structural Biology Institute

Country

France

City

GRENOBLE

Postal Code

38000

Street

71 Avenue des Martyrs

Geofield

Where to apply

E-mail

[email protected]

Contact

City

Grenoble

Website

http://www.ibs.fr

Street

41 rue Jules Horowitz

Postal Code

38027

E-Mail

[email protected]

STATUS: EXPIRED