Analysis of turn-rich bioactive peptide properties through an approach combining solution and solid-state NMR and theoretical calculations

1 May 2024
Job Information

Organisation/Company

UMR 6014 CNRS

Research Field

Chemistry
Chemistry » Biochemistry

Researcher Profile

Recognised Researcher (R2)
Leading Researcher (R4)
First Stage Researcher (R1)
Established Researcher (R3)

Country

France

Application Deadline

25 May 2024 - 22:00 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

1 Oct 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Bioactive peptides have emerged as a promising class of drugs in the field of pharmacology, due to their specificity and their capacity to selectively target distinct biological processes. Their use as therapeutic agents has become widespread, with various administration routes (dry or wet forms). An important question is how the peptide structure may be affected by the nature of the formulation.

The main objective of this project is to evaluate the impact of the physical state of bioactive peptides, especially those rich in turns in drug preformulation stages.  To this end, we plan to develop an approach combining liquid and solid-state NMR, as well as theoretical calculations. We will first investigate the complementarity of liquid and solid-state NMR in beta-turn characterization using model peptides. Then we will apply the developed methodologies to bioactive peptides of interest.

Funding category: Contrat doctoral

PHD title: Doctorat de Chimie
PHD Country: France

Requirements
Specific Requirements

The applicant should have a Master Degree with a speciality in Analytical Chemistry, Physical Chemistry or Structural Biology. He/She must also have taken courses on NMR spectroscopy. Crystallisation, peptide/protein NMR or molecular modeling knowledge would be an asset. Fluency in English (both oral and written) is mandatory.

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

UMR 6014 CNRS

Country

France

City

MONT-SAINT-AIGNAN

Geofield

Where to apply

Website

https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/123498

Contact

Website

https://www.lab-cobra.fr/

STATUS: EXPIRED