24-Month Post-doctoral position in Organic Synthesis, Paris

6 Feb 2024
Job Information

Organisation/Company

Université Paris Cité

Research Field

Chemistry
Biological sciences » Biology

Researcher Profile

Recognised Researcher (R2)
Established Researcher (R3)

Country

France

Application Deadline

6 Mar 2024 - 22:00 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The ANR consortium project (MOCALOST) is dedicated to the isolation and characterization of the oligosaccharides transporter, LOST, which is an orphan key player in the field of glycobiology. Towards this goal our team develops a chemobiology approach to synthesize smart molecular tools. Preliminary results already allowed the chemists, biologists and chemobiologists partners of the project (C. Gravier-Pelletier, UMR 8601 CNRS Paris, S. Moore INSERM UMR 1149 Paris and S. Fort UPR 5301 CERMAV, Grenoble) to identify substrates and inhibitors of this transport. Based on these first results, the goal will be to synthetize, on the one hand, affinity probes to capture and identify LOST by proteomics analysis and, on the other hand, second generation saccharidic fluorogenic probes able to exhibit fluorescence only when being inside the lysosomes for real time lysosomal oligosaccharide transport measurements and fluorescent microscopy using semi-intact cell systems.

Requirements
Specific Requirements

Applicants should have a PhD in organic chemistry with a strong background in multi-step synthesis and purification techniques of complex hydrophilic/polar molecules in normal and reverse phase. An experience in the synthesis of (saccharidic) probes for biology and a strong interest for the interface between chemistry and biology would be a plus. The candidate should have a very good expertise in NMR (1D and 2D), UV and fluorescence analysis techniques. He/she will participate in regular meetings to monitor the project. The ability to communicate and to work in trans-disciplinary teams is important for the success of the project.

 

Salary : Between 2700 € and 3580 € gross monthly, depending on experience after the PhD.

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Université Paris Cité

Country

France

City

Paris

Geofield

Where to apply

Website

https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/119928

Contact

Website

http://lcbpt.biomedicale.parisdescartes.fr

STATUS: EXPIRED