Postdoc in ubiquitin signalling in inflammation and cellular metabolism - DTU Bioengineering

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Postdoc in ubiquitin signalling in inflammation and cellular metabolism - DTU Bioengineering
Kgs. Lyngby, Denmark
Job Description

Do you want to be part of a team that is discovering new fundamental biological mechanisms involved in development of inflammatory disease and cancer?

An excellent opportunity is now available to join Ubiquitin Signalling and Inflammation Lab at the Department of Biotechnology and Biomedicine, Technical University of Denmark (DTU), as a postdoctoral researcher on a 33-months fully funded project.

About the position and project
We are seeking an ambitious and highly motivated postdoc with a background in molecular cell biology or similar and a strong interest in understanding the molecular basis of signalling pathways in disease. The successful candidate will work under the supervision of Associate Professor Rune Busk Damgaard on a project that aims to understand how interplay and crosstalk between inflammatory and metabolic signalling pathways may contribute to cancer development. Specifically, the postdoc will investigate how ubiquitination may regulate crosstalk between metabolic signalling, proinflammatory cytokine signalling, and cell death, and how such crosstalk affects the way cells respond to inflammatory and metabolic stimuli and stresses.

The main tasks in the projects will include:

• Culturing and stimulation of mammalian cells,
• Biochemical analysis of signalling pathways,
• Analysis of protein posttranslational modifications (e.g. ubiquitination and phosphorylation) in response to metabolic and inflammatory stimuli,
• Analysis of protein-protein interactions and multi-protein complex formation,
• Analysis of cell fate outcomes, including inflammatory gene activation and cell death,
• CRISPR-Cas9-mediated gene editing,
• Contributions to student supervision and collaborative projects in the laboratory.

The research project is funded by the Danish Cancer Society.

The Ubiquitin Signalling and Inflammation Lab  uses a combination of molecular cell biology, biochemistry, and quantitative proteomics to unravel the fundamental biological processes that control crosstalk and integration between inflammatory and metabolic signalling pathways. Our ultimate aim is to identify druggable signalling mechanisms that will advance therapy for patients suffering from inflammatory diseases, metabolic disorders, and cancer. 

In the past years, our lab has gained novel insights into how the Met1-linked ubiquitin-specific E3 ubiquitin ligase LUBAC and its counteracting deubiquitinase OTULIN regulate immunologic and metabolic homeostasis and how dysregulation of LUBAC and OTULIN leads to development of autoinflammation, dysmetabolism, and cancer (Damgaard et al., Cell 2016; Damgaard et al., EMBO Mol Med 2019; Damgaard et al., Cell Death Differ 2020; Jahan et al., Cell Death Differ 2021). We are now expanding these efforts to deepen our understanding of how Met1-linked ubiquitin signalling controls cellular responses to metabolic stress and how such pathways and mechanisms may contribute to disease development.

The postdoc will spearhead an ambitious project aiming to identify new molecular mechanisms by which LUBAC and OTULIN regulate the cellular response to metabolic and inflammatory stresses (e.g. nutrient or energy imbalances and TNF-related cytokines) and determine cell fate. Such mechanisms may be druggable and may be involved in the development of metabolic and inflammatory diseases as well as cancer. 

Relevant reading: 

Damgaard et al., Cell (2016): https://pubmed.ncbi.nlm.nih.gov/27523608/

Damgaard et al., EMBO Mol Med (2019): https://pubmed.ncbi.nlm.nih.gov/30804083/

Damgaard et al., Cell Death Differ (2020): https://pubmed.ncbi.nlm.nih.gov/30804083/

Jahan et al., Cell Death Differ (2021): https://pubmed.ncbi.nlm.nih.gov/33441937/

Qualifications and assessment criteria
The successful candidate must:

• hold a PhD degree (or equivalent) in a relevant subject, e.g. biochemistry, cell biology, or immunology
• be ambitious, curious, and highly motivated,
• have advanced experience and a publication record within a relevant research field, e.g. inflammatory signalling, metabolic signalling, or cell death
• have the ability and willingness to work in a collaborative team,
• have excellent communication skills in written and spoken English,
• have ability and drive to independently develop research projects,
• have the persistence to work on challenging tasks and succeed in a competitive research field,

Essential skills and competences:

• extensive experience in cell and molecular biology, including molecular cloning, immunoblotting (western blot), and immunoprecipitation, 
• extensive experience with mammalian cell culture, including cell stimulation and transfection

The ideal candidate will have one or more of these desirable - but not essential - skills and competences:

• Research experience within any or multiple of these fields: inflammation and cytokine signalling, cell death, metabolic signalling, autophagy, lysosome or mitochondrial biology, or the ubiquitin system,
• Experience with CRISPR/Cas9-mediated gene editing.

About the research group
The successful candidate will join a vibrant, ambitious, and international research team. The Ubiquitin Signalling and Inflammation Lab  offers a collaborative, supportive, and dynamic work environment focusing on excellence in research and mentoring. Read more about the lab and our research here: http://bioengineering.dtu.dk/usi

The Ubiquitin Signalling and Inflammation Lab  is embedded in the Department of Biotechnology and Biomedicine, Technical University of Denmark. The department is highly interdisciplinary and a leading department within life sciences in Denmark, covering both fundamental, technological, and applied aspects of biomedical research. The Department offers access to a large suite of state-of-the-art core facilities, including proteomics, bioimaging, biophysics, and structural biology.

Assessment
The assessment of the applicants will be made by Associate Professor Rune Busk Damgaard together with relevant project partners.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

Salary and terms of employment 
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 33 months.

You can read more about career paths at DTU here .

Starting date is 1 May 2024 (or as agreed upon by all parties). The position is a full-time position.

Further information
Informal enquiries and requests for further information should be directed to Associate Professor Rune Busk Damgaard ([email protected] )

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark .

Application procedure 
Your complete online application must be submitted no later than 25 February 2024 (23:59 Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

• A cover letter describing your motivation, ambition, and how your technical skills are suited for the project,
• Detailed curriculum vitae (CV),
• List of publications,
• Academic Diplomas (MSc/PhD – in English),
• Names and contact details (including email address and phone number) for at least two academic references.

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science- and biotech industries and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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Job Info

• Job Identification 2972
• Job Category VIP B
• Posting Date 01/15/2024, 12:00 AM
• Apply Before 02/25/2024, 05:59 PM
• Locations Søltofts Plads, Kgs. Lyngby, 2800, DK

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