Postdoc in Organelle Quality Control by Autophagy

Updated: about 1 month ago
Job Type: FullTime
Deadline: 15 Jun 2024

4 May 2024
Job Information
Organisation/Company

Aarhus University
Department

Aarhus Institute of Advanced Studies
Research Field

Biological sciences
Medical sciences
Researcher Profile

First Stage Researcher (R1)
Country

Denmark
Application Deadline

15 Jun 2024 - 23:59 (Europe/Copenhagen)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

38
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The Department of Biomedicine at the Faculty of Health at Aarhus University invites applications for a position as postdoctoral fellow within the research area as of Organelle Quality Control by Autophagy per 1st August 2024 or as soon as possible thereafter. The position is a fixed-term, full-time position for 4 years.

The Department of Biomedicine prioritizes diversity and a good work environment, as this is a prerequisite for groundbreaking research. In a dynamic and international research environment, dedicated employees are looking to generate new knowledge within biomedical research areas such as infection and inflammation, membranes, neuroscience and personalized medicine. The Department of Biomedicine provides research-based teaching of the highest quality and is responsible for a large part of the medical degree programme. Academic staff contribute to the teaching. English is the preferred language in the laboratory, at meetings and at seminars. The department employs approx. 500 people from all over the world, and they make use of the department's modern laboratory-, core- and animal facilities. The Department of Biomedicine focuses on innovation, entrepreneurship and collaboration with business and industry, and numerous researchers from the department have established companies to develop new medicinal treatments founded in strong scientific basic research. You can read more about the department here and about the faculty here .


About the research project

Autophagy is a catabolic process highly conserved among eukaryotes, which is involved in the degradation of long-lived proteins, aberrant complexes and aggregates, dysfunctional and superfluous organelles, and intracellular pathogens. Structures targeted to destruction, including intracellular organelles, are sequestered by double-membrane vesicles called autophagosomes and delivered to lysosomes for turnover. The central players of autophagy are the autophagy-related (ATG) proteins. Autophagy can be highly selective and target specific unwanted structures using the so-called selective autophagy receptors (SARs) and various adaptor proteins.

The overall aim of the project is to understand the relevance of autophagy, ATG proteins and SARs in the quality control of intracellular organelles such as the endoplasmic reticulum, mitochondria and peroxisomes. The overall idea is to identify how these players sense and then mediate the turnover of local dysfunctions in these organelles.


Requirements
Research Field
Biological sciences » Biology
Education Level
PhD or equivalent

Skills/Qualifications
Your competences

You have an academic qualification at the PhD level, preferably within one or more of the following areas: cell biology and/or biochemistry. The applicant must have experience in cell culture (including transfection, siRNA-based knockdown…). A plus will be familiarity with CRISPR/Cas9 knockout and knock-in technologies.

Moreover, the applicant has to be familiar with live-cell fluorescence microscopy and immunofluorescence, but also have training in molecular biology (PCR, RT-PCR, cloning, DNA gel electrophoresis…) and biochemical techniques (SDS-PAGE, western blot, immunoprecipitations…). Previous experience in the field of autophagy and/or protein/organelle quality control will be an advantage.

As a person, you are ambitious, take ownership of the project and possess good communication and interpersonal skills.


Specific Requirements
Your job responsibilities

As Postdoc in cell biology/biochemistry, your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on related projects, but not only.

Your main tasks will consist of:

  • Independent research of high international quality, including publications.
  • Work in close collaboration with the other member of the laboratory.
  • Participation and presentations at national and international conferences.
  • Active participation to the group and departmental activities.
  • Co-supervise at least one PhD student in the lab.

Languages
ENGLISH
Level
Excellent

Research Field
Biological sciences » Biology

Additional Information
Benefits
Terms of employment
  • Appointment as a postdoc requires academic qualifications at PhD level.
  • Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities .
  • The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).
  • Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health .
  • The yearly base salary for a fulltime postdoc is between DKK 484.214,84 and DKK 538.720,20 depending on the years of working experience after achieved MSc degree. The base salary includes a position related supplement and pension (17.1 %). Additional supplement(s) for special qualifications can be negotiated. Authorisation supplemement(s) will be granted, if relevant for the position. Your local eligible trade union representative at Aarhus University negotiates your salary on your behalf.
  • Researchers recruited from abroad are offered a special researcher tax scheme with a lower tax rate.
  • Further information on qualification requirements and job description can be found in the Ministerial Order on Job Structure for Academic Staff

Work Location(s)
Number of offers available
1
Company/Institute
Department of Biomedicine, Aarhus University
Country
Denmark
City
Aarhus
Postal Code
8000
Geofield


Where to apply
Website

https://health.au.dk/en/about-health/vacant-positions/job/postdoc-in-organelle-…

Contact
City

Aarhus
Website

http://aias.au.dk
Street

Høegh Guldbergs Gade 6B
Postal Code

8000
E-Mail

[email protected]
Phone

004587159527
Mobile Phone

004524203135

STATUS: EXPIRED

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