Postdoc in hiPSCs, neuron-glial interactions and single-cell omics - DTU Bioengineering

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Postdoc in hiPSCs, neuron-glial interactions and single-cell omics - DTU Bioengineering
Kgs. Lyngby, Denmark

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Job Description

We are looking for a highly motivated postdoctoral fellow for a 3-year postdoc position, to join the group of Associate Professor Kedar Natarajan from the 1 October 2024 or as soon as possible.
Our research
Our group investigates mechanisms underlying cell-fate decisions in stem cells (ES/iPS) and during differentiation to cell types of the central nervous system (CNS). To achieve this, we use patient-derived and disease specific hiPSC and their differentiation to neurons, microglia and model neurodevelopmental trajectories through single-cell profiling including single-cell transcriptomics, ATAC-seq, multi-omics and spatial transcriptomics. We also develop and leverage computational approaches for identifying gene regulatory networks and candidate perturbation to study systems levels changes and specific underlying mechanisms. In this new project, we aim to develop and study neuron-glial interactions in co-cultures, coupled with single-cell multi-modal assays to characterize gene regulatory networks. We will focus on investigating targets including CRISPR perturbations to study target roles in neuron-glial interaction, cell type differentiation and responses.

The group is highly collaborative and interdisciplinary, and is part of PSBT section at DTU Bioengineering. The candidate will interact with with other groups at DTU Bioengineering, Health Technology and international partners. More details can be found at group page (http://www.bioengineering.dtu.dk/Kedar-Natarajan)

 

Project description
The successful candidate is expected to work on a project involving implementation of patient- and disease-specific ES/iPS derived co-culture systems for neural-glial interactions, single-cell profiling and CRISPR based candidate perturbation, to understand global systems level changes as well as specific targets and mechanisms. The project is highly interdisciplinary and will include primarily experimental work (i.e., ES/iPS culture and differentiation to neurons and glial cells (microglia) and co-culture systems, assessment and monitoring of culture with single-cell profiling, gene editing and working with bioinformaticians on data analysis. Interest and prior computational experience is welcome and would be useful to the project.

As a part of a multidisciplinary team and research environment, a collaborative mindset and proven ability to work in teams and communicate scientific research through presentations and submitted manuscripts is expected. The candidate is expected to perform this independent project with high degree of autonomy in planning and design, and also work positively with other team members towards a collaborative environment. In this specific project, you will be working closely with 3 other members (PhD and postdocs) and supported by computational PhD student. Candidates with strong academic track record, publications and positive references are valued. If you are highly driven, you will have opportunities to write grants for further strengthening research opportunities and participate in the broader collaborations.

Profile
We are looking for a motivated and enthusiastic researcher with following competences:

Essential experience and skills:

•   PhD in Neuroscience, Developmental/stem cell biology, Biotechnology, or a comparable field
•   Proficiency in hES/iPS cultures, differentiation to neuronal and glial cells and cell type characterisation (Imaging, Mol. Bio, functional assays).
•   Track record/publications in neuroscience research
•   High proficiency in spoken and written English

Desirable experience and skills:
•   Prior experience with genome editing
•   Prior experience with single-cell transcriptomics (experimental or computational analysis)
As a formal qualification, you must hold a PhD degree (or equivalent).

You will be primarily based at DTU Bioengineering, and interact locally with other bioinformatics colleagues and groups at Bioengineering and DTU Health Technology, as well as our national, international partners.

Assessment

The assessment of the applicants will be made by Associate Professor Kedar Natarajan together with relevant project partners.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment 
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 3 years.

You can read more about career paths at DTU here .

Further information 
Further information may be obtained from Assoc. Prof. Kedar Natarajan ([email protected]
You can read more about the lab at Transcriptional Regulation and Single-Cell Systems Genomics (dtu.dk)  and DTU Bioengineering at www.bioengineering.dtu.dk/english   

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark .

Application procedure 
Your complete online application must be submitted no later than 15 August (23:59 Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

•   Cover letter describing your relevant scientific interests, competences and how that aligns with the focus of the project and group
•   CV containing education, prior research experience/employments with contact information for 2 referees
•   List of publications
•   Certified/signed copy of PhD certificate (if PhD degree is not awarded, a written statement from supervisor/PhD school will be fine)
•   Two reference letters

Incomplete applications will not be considered. You may apply prior to obtaining your master's degree but cannot begin before having received it. Applications received after the deadline will not be considered. All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing  bio-based economy and with health systems transforming towards  personalized medicine. We have a clear focus on the needs in the life  science industry and point towards innovation, new businesses, and  scientific services for the benefit of society. The department has  extensive collaborations with national and international research units  and industry. DTU Bioengineering has approx. 400 employees, of which 2/3  are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.


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Job Info
  • Job Identification 3638
  • Job Category VIP B
  • Posting Date 06/10/2024, 09:14 AM
  • Apply Before 08/15/2024, 05:59 PM
  • Locations Søltofts Plads, Kgs. Lyngby, 2800, DK



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