POSTDOC IN CELL BIOLOGY (2024-224-05911)

A Postdoc position is available to explore the enigmas of intracellular signal transduction with a focus on the calcium(Ca2+ ) feedback loop in IP3/Ca2+ -signaling. IP3 stimulates the release of Ca2+ stored in the endoplasmic reticulum through IP3 receptors(IP3Rs). A critical aspect of Ca2+ -signaling is the ability of Ca2+ to self-regulate by feedback mainly mediated by the Ca2+ -binding protein calmodulin(CaM). When Ca2+ binds, the shape of CaM changes, enabling it to modulate the activity of the IP3Rs. Mutations in CaM cause deadly cardiac arrhythmias and neurological disorders, much like diseases caused by perturbations of the InsP3/Ca2+ signaling pathways. Despite the universality and intersection of these pathways, the mechanisms by which CaM regulates the IP3Rs remain unresolved. Moreover, whether altered IP3R regulation is involved in pathology due to mutations in CaM is entirely unknown.

In this postdoc position, you will address these unexplored avenues by biophysical and cellular approaches. You will take part in designing and implementing protocols to study the interaction between the IP3Rs and CaM and to unveil the underlying mechanism of modulation. The project is headed by Assistant Professor Malene Brohus and funded by the Independent Research Fund Denmark.

You may obtain further information about the project by e-mail: [email protected] . 

The workplace is in Aalborg and the prospective postdoc will become an integrated part of the Medical Biotechnology section, located at Fredrik Bajers Vej 7H, 9220 Aalborg East, Denmark.

Qualification requirements: 

Appointment as Postdoc presupposes scientific qualifications at PhD–level or similar scientific qualifications in cell biology or in a closely related field. The applicant must be experienced in mammalian cell culture and microscopy techniques with a documented track-record related to these competencies. Experience with calcium signaling and calcium imaging is considered a great advantage, as is experience with biochemical and biophysical methods.

The applicant must be highly motivated and able to work systematically and independently, using problem-solving skills and critical thinking, in an interdisciplinary research environment. Excellent oral and written English language skills are a requirement, as well as a cooperative personality and good communication skills. The research potential of each applicant will be emphasized in the overall assessment. Appointment as a Postdoc cannot exceed a period of four years in total at Aalborg University.

The application must contain the following:

• A motivated text wherein the reasons for applying, qualifications in relation to the position, and intentions and visions for the position are stated.

• A current curriculum vitae.

• Copies of relevant diplomas(Master of Science and PhD). On request you could be asked for an official English translation.

• Scientific qualifications. A complete list of publications must be attached with an indication of the works the applicant wishes to be considered. You may attach up to 5 publications.

• Dissemination qualifications, including participation on committees or boards, participation in organisations and the like.

• Additional qualifications in relation to the position. References/recommendations.

The applications are only to be submitted online by using the"Apply online" button below.

Shortlisting will be applied. After the review of any objections regarding the assessment committee, the head of department, with assistance from the chair of the assessment committee, selects the candidates to be assessed. All applicants will be informed as to whether they will advance to assessment or not.

Aalborg University wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background or belief.

For further information concerning the application procedure please contact Lisette Sisse Belby by mail[email protected] .

Information regarding guidelines, ministerial circular in force and procedures can be seen here  

Employment is in accordance with the Ministerial Order on the Appointment of Academic Staff at Universities(the Appointment Order) and the Ministry of Finance's current Job Structure for Academic Staff at Universities. Employment and salary are in accordance with the collective agreement for state-employed academics.