Postdoctoral Position in Mathematical and Computational Biology/Biophysics

Updated: about 2 months ago
Job Type: FullTime
Deadline: 10 May 2024

3 Apr 2024
Job Information

J. Heyrovský Institute of Physical Chemistry of the CAS, v. v. i.
Research Field

Physics » Biophysics
Mathematics » Applied mathematics
Researcher Profile

Recognised Researcher (R2)

Czech Republic
Application Deadline

10 May 2024 - 23:00 (Europe/Prague)
Type of Contract

Job Status

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?


Offer Description

The Timr group  at the J. Heyrovský Institute of Physical Chemistry in Prague  is seeking a highly motivated postdoctoral associate to work on multi-scale modeling of dynamic enzyme assemblies.

Our research group focuses on the computer simulation of the cell interior. Using multi-scale computational models, we aim to elucidate the physical and chemical mechanisms governing the organization of metabolic pathways in living cells. Supported by the Lumina Quaeruntur Award and a grant from the Czech Science Foundation, our team is integrated into the interdisciplinary Department of Computational Chemistry . This department bridges the physical chemistry and biophysics of proteins and membranes with theoretical enzymology and spectroscopy.

The postdoctoral associate will develop mesoscopic computational models to understand the roles of dynamic enzyme assemblies in metabolic regulation. The goal is to develop and implement a novel framework that will integrate detailed insights from all-atom and coarse-grained MD simulations with larger-scale reaction-diffusion models of dynamic enzyme assemblies. This work will be an important contribution to our mechanistic understanding of metabolic pathway organization in cells.

The initial contract period is for one year, possibly extending up to four years. The position will remain open until a suitable candidate is found.


  • PhD in a quantitative field, such as Mathematical/Computational Biology, Biophysics, Chemical Engineering, or Applied Mathematics.
  • Strong skills in developing and implementing mathematical models.
  • Proficiency in programming and scripting languages (e.g., Python, C++) for model development and data analysis.
  • Excellent communication and collaboration skills.

Experience in kinetic modeling of enzymes and metabolic pathways, reaction-diffusion modeling, classical MD simulations, and Markov models will be considered an asset.

To apply, please send your CV, a list of publications, a motivation letter, and contact information for two references to [email protected]  and [email protected] . Please include SC2024_15 in the email subject line. For any inquiries, contact [email protected] .

Starting date: The position is available immediately.

Type of contract: Temporary

Job status: Full time

Selection process

By providing us with your personal data in your CV, you have allowed J. Heyrovský Institute of Physical Chemistry to process and file your CV in the HR database. Your personal data will be used for the internal HR needs of the J. Heyrovský Institute of Physical Chemistry only. At the same time, you confirm herewith that the personal data as stated in the CV you have sent to us is true and accurate.

Research Field
Education Level
PhD or equivalent

Research Field
Education Level
PhD or equivalent

Additional Information
Work Location(s)
Number of offers available
J. Heyrovský Institute of Physical Chemistry of the CAS, v. v. i.
Czech Republic

Where to apply

[email protected]


Czech Republic

Prague 8

Dolejškova 2155/3
Postal Code

182 23

[email protected]


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