PhD student in medical mycology

Updated: 5 months ago
Deadline: 11 Dec 2016

Job posted by KU Leuven (09/11/2016 01.45)
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The Laboratory of Clinical Bacteriology and Mycology in the Department of Microbiology and Immunology - University of Leuven (KU Leuven) - Belgium has a vacant position for a PhD student in medical mycology.


Description

The mission of our laboratory is to improve the diagnosis and treatment of invasive fungal infections. The Leuven International Doctoral School Biomedical Sciences is a lively community counting over 1200 PhD researchers, more than 250 supervisors and a dedicated administrative staff.
Aspergilli are ubiquitous in the environment and cause a whole spectrum of human diseases including invasive life threatening infections in immunocompromised hosts. Triazole antifungal drugs are currently the cornerstones of prophylaxis and treatment of Aspergillus-releated diseases but global emergence of triazole resistance is a concern. Exposure of Aspergillus fumigatus to azole fungicides in the environment is believed to be an important route of resistance selection.

The aims of this project are:

- to gain a better insight in the evolving epidemiology of azole resistant A. fumigatus and the resistance mechanisms involved, through surveillance  and molecular analysis of triazole resistant A. fumigatus isolates retrieved within the context of an international network (Aspergillus Resistance Surveillance working group from the International Society of Human and Animal Mycology, ISHAM, coordinators Prof dr Paul E.Verweij, the Netherlands, Prof dr Katrien Lagrou, Belgium, Prof dr A.Chowdhary, India and Dr SR Lockhart, USA). 25 centers have expressed interest to participate. These centers are well spread geographically including Europe, Middle East, Asia, Australia, Africa and the United States

- to evaluate the influence of resistance mechanisms on in vivo growth and disease progression in an established mouse model of invasive aspergillosis through multimodal imaging and biomarker testing in the presence or absence of antifungal prophylaxis/treatment and in a setting of mono- or mixed infection.

Nr of positions available : 1

Please note that the full description may be available in the national language since some job boards have their own publication policy. Thank you for your understanding!


Research Fields

Biological sciences - Biology
Medical sciences - Medicine


Career Stage

Early stage researcher or 0-4 yrs (Post graduate)


Research Profiles

Not defined


Benefits

We offer a full time doctoral student research position for 4 years. The research output should result in a PhD degree.A stimulating work environment with direct contact with the University Hospitals of Leuven (a large tertiary care hospital) and molecular Small Animal Imaging Centre (moSAIC).


Comment/web site for additional job details

Reference number BAP-2016-579
- Master in medicine, pharmaceutical sciences,biomedical sciences or equivalent with outstanding study results.
- You are fluent in interdisciplinary English communication.
- You are critical, flexible, independent, creative, a team-player, willing to conduct rodent experiments and eager to emerge yourself in the complex clinical setting of invasive fungal infections.

For more information please contact Prof. dr. Katrien Lagrou, tel.: +3216347098, mail: katrien.lagrou@kuleuven.be.
Please submit your motivation letter and detailed CV (incl. courses, grades, previous work, publications) through the online application tool (see below).
You can apply for this job no later than 11/12/2016 via the online application tool


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